INTRODUCTION Methadone has been used as a drug to detoxify opioid tolerance. Naloxane precipitated morphine withdrawal behaviours were attenuated by venlafaxine as an antidepressant. On the contrary, after detoxifying the opioids, spontaneous withdrawal syndrome may occur with pain sensitivity. Therefore the present study aimed to examine the effects of chronic methadone (70 mg/kg, in drinking ...

Altered pain responding in depression is a widely recognized but poorly understood phenomenon. The present study investigated nociceptive responding to acute (thermal and mechanical) and persistent (inflammatory) noxious stimuli in two animal models of depression, the olfactory bulbectomized (OB) and the Wistar-Kyoto (WKY) rat. In addition, this study examined if altered nociceptive behaviour w...

A new series of cyclooxygenase-2 inhibitors with 2-amino-5-sulfanyl-1,3,4-thiadiazole as the central scaffold unit has been synthesized. The newly synthesized compounds were characterized by analytical and spectral methods. Compounds were screened for cyclooxygenase inhibitory activity by the colorimetric COX (ovine) inhibitor screening assay, anti-inflammatory activity by the carrageenean indu...

The chemical and analgesic comparison of essential oils o Congo was investigated. The Chemical analysis wa carried out by u the two essential oils while acetic acid-induced writhings, hot plate activity. The results showed that the two essential oils exhibite writhings, however, the essential oil of Benin induced more significa specie showed more effect in the tail flick test. These observation...

WALKER, J. M. AND W. C. DIXON. A solid state device for measuring sensitivity to thermal pain. PHYSIOL BEHAV 30(3) 481-483, 1983.--A simple and inexpensive circuit for use in conducting the tail-flick test is described. The use of digital integrated circuits coupled to a thyristor phase control circuit holds the number of parts needed to minimum. Methods for the use of the device and statistica...

The influence of tiagabine at a dose of 3.2 mg/kg (single administration) and at a dose of 1.2 mg/kg (multiple administration - 10 days) on the antinociceptive effect of morphine (10 mg/kg), metamizole (500 mg/kg) and indomethacin (10 mg/kg - single dose and 1.4 mg/kg - multiple doses) was investigated in mice using the hot-plate and tail-flick tests. All drugs were injected intraperitoneally. ...

Purpose: To investigate the active fraction of pomegranate fruit extract and screen it for analgesic activity. Methods: The analgesic activity of pomegranate ethyl acetate fraction (EtOAc) was examined using three models of pain: writhing, hot tail flick and plantar tests. EtOAc was administered by oral gavage in doses of 100, 150 and 200 mg/kg, p.o., for all the tests and compared to aspirin (...

Smilax canariensis Brouss. ex Willd. is an endemic plant of the Canary Islands. Its rhizomes, leaves and stems have been traditionally used in Canary folk medicine to treat a wide variety of conditions including pain. Our objective is to investigate the analgesic and anti-inflammatory activities of different extracts of S. canariensis in Swiss mice, using established biological models for pain ...

Pain is relieved by analgesics that acts via modulating the central and peripheral pain mediators. Some of analgesic has been reported to have a serious adverse effects when used in long-term treatments. Therefore, there need developing potent with minimal no effects. In current study, quercetin chrysin were evaluated for activity mice rat hyperalgesia (Eddy’s hot plate Tail flick analgesiomete...

Introduction: Methadone has been used as a drug to detoxify opioid tolerance. Naloxane precipitated morphine withdrawal behaviours were attenuated by venlafaxine as an antidepressant. On the contrary, after detoxifying the opioids, spontaneous withdrawal syndrome may occur with pain sensitivity. Therefore the present study aimed to examine the effects of chronic methadone (70 mg/kg, in dr...