نتایج جستجو برای: tad
تعداد نتایج: 734 فیلتر نتایج به سال:
The conformation of HIV-1 envelope (Env) glycoprotein trimers is key in ensuring protection against waves of neutralizing antibodies generated during infection, while maintaining sufficient exposure of the CD4 binding site (CD4bs) for viral entry. The CD4 binding loop on Env is an early contact site for CD4 while penetration of a proximal cavity by CD4 triggers Env conformational changes for en...
The Msn2 and Msn4 transcription factors play crucial roles in the yeast general stress response. Previous studies identified several large functional domains of Msn2, mainly through crude truncations. Here, using bioinformatics and experimental approaches to examine Msn2 structure-function relationships, we have identified new functional motifs in the Msn2 transcriptional-activating domain (TAD...
Mammalian chromosomes fold into arrays of megabase-sized topologically associating domains (TADs), which are arranged into compartments spanning multiple megabases of genomic DNA. TADs have internal substructures that are often cell type specific, but their higher-order organization remains elusive. Here, we investigate TAD higher-order interactions with Hi-C through neuronal differentiation an...
ID: 46 for Promedica International CME (Auto-Generated January 27, 2017 10:37 am) Effects of hospital volume and aortic segments on in-hospital mortality for patients with thoracic aortic disease (TAD) in England by Mohamad Bashir | Amer Harky | Prity Gupta | Giovanni Mariscalco | Consortium of surgeons | Rakesh Uppal | Aung Oo Abstract Id: 46 Submitted: January 26, 2017 Event: The Houston Aort...
Thermophilic anaerobic digestion (TAD) technology has been adopted worldwide mainly due to it being a pathogen-free process in addition the enhanced biogas yield and short hydraulic retention time (HRT). Taking high metabolic rate of thermophilic microbial community with highly efficient enzymatic systems into consideration, thermophiles are widely explored as inocula for lignocellulosic biomas...
[1] We measured the hyporheic residence time distribution in a 2nd-order mountain stream at the H. J. Andrews Experimental Forest, Oregon, and found it to be a power-law over at least 1.5 orders of magnitude in time (1.5 hr to 3.5 d). The residence time distribution has a very long tail which scales as t , and is poorly characterized by an exponential model. Because of the small power-law expon...
Disruptions of Topological Chromatin Domains Cause Pathogenic Rewiring of Gene-Enhancer Interactions
Mammalian genomes are organized into megabase-scale topologically associated domains (TADs). We demonstrate that disruption of TADs can rewire long-range regulatory architecture and result in pathogenic phenotypes. We show that distinct human limb malformations are caused by deletions, inversions, or duplications altering the structure of the TAD-spanning WNT6/IHH/EPHA4/PAX3 locus. Using CRISPR...
The therapeutically relevant hypoxia inducible factor HIF-1α-p300 protein-protein interaction can be orthosterically inhibited with α-helix mimetics based on an oligoamide scaffold that recapitulates essential features of the C-terminal helix of the HIF-1α C-TAD (C-terminal transactivation domain). Preliminary SAR studies demonstrated the important role of side-chain size and hydrophobicity/hyd...
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