AIMS The progression of human heart failure is associated with increased protein phosphatase 1 (PP1) activity, which leads to a higher dephosphorylation of cardiac regulatory proteins such as phospholamban. In this study, we tested the hypothesis whether the inhibitor-2 (I-2) of PP1 can mediate cardiac protection by inhibition of PP1 activity. METHODS AND RESULTS We induced pressure overload ...

The Text Analysis Conferences (TAC) offer a unique occasion to show innovative approaches to text summarization. As a first incursion into this new research area, LIPN participated in the Update Summarization task of TAC 2008. The LIPN wanted to improve the results obtained during TAC 2008 and to confirm that the changes made to its summarization system really enhanced the quality of the automa...

The objective of this article was to review the effects of xenobiotics on total antioxidant capacity (TAC). Measurement of TAC is appropriate for evaluation of the total antioxidant defenses of blood, cells, and different kinds of tissues and organs. TAC is reduced by alcoholism, smoking, and exposure to radiation, herbicides, carbon monoxide, carbon tetrachloride, lead, arsenic, mercury, cadmi...

BACKGROUND More than one-third of hepatocellular carcinoma (HCC) patients are diagnosed at advanced stage with portal vein tumor thrombosis (PVTT) or extrahepatic metastasis. However, the outcomes of current therapeutic approaches are unsatisfactory. As a novel therapeutic strategy for unresectable HCC with PVTT, we analyzed the outcomes of transarterial infusion of epirubicin and cisplatin com...

BACKGROUND Long non-coding RNAs (lncRNAs) are a class of RNA molecules with diverse regulatory functions during embryonic development, normal life, and disease in higher organisms. However, research on the role of lncRNAs in cardiovascular diseases and in particular heart failure is still in its infancy. The exceptionally well conserved nuclear lncRNA Metastasis associated in lung adenocarcinom...

methylsulfonylmethane (msm) is a sulfur-containing compound commonly found in diet and known to reduce oxidative stress. this trial was conducted to determine whether single dose supplementation with msm attenuates post-exercise oxidative stress in healthy untrained young men. sixteen untrained men volunteered for this study. participants were randomized in a double-blind placebo-controlled fas...

Gray and Loh (1) have shown previously that dietary ƒ¿-tocopheryl acetate (ƒ¿ TAc) brings about increases in phospholipids, total and free cholesterol in the plasma of healthy human subjects. It seemed probable that the dietary ƒ¿TAc affected the liver cell itself, the blood being merely a transport medium. This hypothesis was investigated, using rat liver homogenates from animals main tained f...

The Trading Agent Competition (TAC) is an open-invitation forum designed to encourage research into electronic markets and trading agents. In this paper we present the Socrates trading agent and the strategies that were developed for and used in the TAC Supply Chain Management game as part of the 2004 competition. The resulting behaviour and performance in the TAC competition as well as in a se...

In this paper we present our participation at TAC 2009 AESOP (Automatically Evaluating Summaries Of Peers) task. We make use of a statistical model for evaluation metric correlating to Overall Responsiveness and a nugget-based pyramid model for correlating to the Pyramid manual metric of TAC 2009. We also present the performance of our three submitted runs as per the official TAC 2009 evaluatio...

The n_TOF Collaboration has built and commissioned a high-performance detector for ðn;gÞ measurements called the Total Absorption Calorimeter (TAC). The TAC was especially designed for measuring neutron capture cross-sections of low-mass and/or radioactive samples with the accuracy required for nuclear technology and stellar nucleosynthesis. We present a detailed description of the TAC and disc...