The aim of this study was to prepare, using taste-masked granules, tablets which can rapidly disintegrate in saliva (rapidly disintegrating tablet), of drugs with bitter taste (pirenzepine HCl or oxybutynin HCl). The taste-masked granules were prepared using aminoalkyl methacrylate copolymers (Eudragit E-100) by the extrusion method. None of the drugs dissolved from the granules (% of dissolved...

The improvement of pharmaceutical dosage forms, such as tablets, towards drug delivery control and cost efficiency is of great importance in formulation technologies. Here, three examples: in situ coating, freeze casting and protein-based biocomposites are presented that address the above mentioned issues and contribute to further developments in formulation technologies. The in situ coating in...

The purpose of the present research was to prepare and evaluate mannitol and cellulose based, directly compressible excipient using freeze-thawing technique. The mannitol to cellulose ratio (50:50, 60:40, and 70:30) and the rotation speed of propeller stirrer (200, 600, and 1000 rpm) were selected as independent variables in a 3 full factorial design. Water acted as a good medium for mannitol a...

mulation and in many cases the bioavailability of drug from tablets has received considerable attention. As part of the efforts to reach international harmonization of pharmaceutical excipients, the Joint Conference on Excipients identified starch as one of the top 10 excipients (1). Starch is a multipurpose excipient in tablet formulation, and it is used as a binder, disintegrant, and filler (...

Tablet dissolution is strongly affected by swelling and solvent penetration into its matrix. A terahertz-pulsed imaging (TPI) technique, in reflection mode, is introduced as a new tool to measure one-dimensional swelling and solvent ingress in flat-faced pharmaceutical compacts exposed to dissolution medium from one face of the tablet. The technique was demonstrated on three tableting excipient...

Development of quality estimation models using near infrared spectroscopy (NIRS) and multivariate analysis has been accelerated as a Process Analytical Technology (PAT) tool in the pharmaceutical industry. Although linear regression methods such as partial least squares (PLS) are widely used, they may not be able to achieve high estimation accuracy because physical and chemical properties of a ...

Budesonide, a potent glucocorticoid, is used for the treatment of inflammatory bowel diseases. Current available oral formulations of budesonide have low efficacy against ulcerative colitis because of the premature drug release in the upper part of the gastrointestinal tract. In this paper a pH- and time-controlled colon-targeted pellet-based tablet of budesonide was established. Pellet cores w...

Purpose: The microcrystalline cellulose is an important ingredient in pharmaceutical, food, cosmetic and other industries. This study aimed at evaluating the physical characteristics of microcrystalline cellulose (CP-MCC), obtained from the raw cotton of Cochlospermum planchonii. Methods: CP-MCC was obtained from the raw cotton by a two-stage sodium hydroxide treatment process followed by sodiu...

In the present study Rizatriptan benzoate, which is the bitter drug requires taste, masking. βCyclodextrin is used in taste masking, which improves the patient compliance and also increases the rate of dissolution. Solid dispersion of drug and βCyclodextrin were prepared which was optimised in 1: 8 ratios, which gave satisfactory results for taste masking. This was then characterised using Diff...

In the present work Loratadine and Phenylephrine Bilayer tablets were prepared by compressing Loratadine layer as direct compressible layer which is an immediate release layer and Phenylephrine hydrochloride by wet granulation method as sustained release layer which are compressed using Bilayer tableting machine. The tablets were evaluated for thickness, hardness, friability, and weight variati...