Type 2 diabetes (T2D) is a complex and heterogeneous disease. Obesity increases the risk of obese T2D; but in Asia non-obese T2D is prevalent. The cause of non-obese T2D has remained elusive. We studied the potential involvement of HGK/MAP4K4 in T2D using clinical samples from newly diagnosed, drug-naïve patients and healthy controls. HGK levels fell and IL-6 levels increased in T cells from T2...

Insomnia increases type-2 diabetes (T2D) risk. The 12q24 locus is linked to T2D, depression, bipolar disorder and anxiety. At the 12q24 locus, the Proteasome-Modulator 9 (PSMD9) single nucleotide polymorphisms (SNPs) rs74421874 [intervening sequence (IVS) 3+nt460-G>A], rs3825172 (IVS3+nt437-C>T) and rs14259 (E197G-A>G) are linked to: T2D, depression, anxiety, maturity-onset-diabetes-of the youn...

BACKGROUND Prospective data regarding persistent organic pollutants (POPs) and risk of type 2 diabetes (T2D) are limited, and the results for individual POPs are not entirely consistent across studies. OBJECTIVES We prospectively examined plasma POP concentrations in relation to incident T2D and summarized existing evidence in a meta-analysis. METHODS Plasma polychlorinated biphenyls (PCBs)...

We aimed at evaluating the effect of short-duration stair climbing–descending exercise (ST-EX) on 24-hour blood glucose (BG) response in people with type 2 diabetes (T2D). Seven men (age, 70.1 ± 1.3 years) uncomplicated T2D consumed three meals per day according to a meal plan for patients diabetes. Participants completed one session ST-EX 60 and 120 min after each first (ST-EX day), did not pe...

BACKGROUND There is emerging evidence linking diabetes with periodontal disease. Diabetes is a well-recognized risk factor for periodontal disease. Conversely, pro-inflammatory molecules released by periodontally-diseased tissues may enter the circulation to induce insulin resistance. While this association has been demonstrated in adults, there is little information regarding periodontal statu...

Data from animal experiments strongly suggest that ceramide is an important mediator of lipotoxicity in the heart and that accumulation of ceramide contributes to cardiomyocyte apoptosis associated with type 2 diabetes and obesity. However, it remains unknown whether a similar relationship is present also in the human heart. Therefore, we aimed to examine whether myocardial apoptosis in obese a...

Aim . To study clinical and paraclinical parameters lesions of the coronary bed in patients with acute types artery disease (CAD) type 2 diabetes (T2D). Material methods The included 102 both sexes CAD. Patients were analyzed two following groups: first (mean age, 56,6±0,96 years, men/women 34/16) consisted 50 syndrome (ACS) diabetes, second 58,7±1,01 37/15) — 52 without T2D. Along assessment b...

Twin studies of diabetes mellitus can help elucidate genetic and environmental factors in etiology and can provide valuable biological samples for testing functional hypotheses, for example using expression and methylation studies of discordant pairs. We searched the volunteer Australian Twin Registry (19,387 pairs) for twins with diabetes using disease checklists from nine different surveys co...

A large proportion of heritability of type 2 diabetes (T2D) has been attributed to inherent genetics. Recent genetic studies, especially genome-wide association studies (GWAS), have identified a multitude of variants associated with T2D. It is thus reasonable to question if these findings may be utilized in a clinical setting. Here we briefly review the identification of risk loci for T2D and d...

Approximately 50 million Muslim adults with type 1 diabetes (T1D) and type 2 diabetes (T2D) go without food or drink from sunrise to sunset during the month of Ramadan, despite having a religious exemption.1 For many Muslim people with diabetes, Ramadan is a religious conviction and the intermittent fasting is a key component of its observance. The EPIDIAR (Epidemiology of Diabetes and Ramadan)...