BACKGROUND Myocardial T1, T2 and T2* imaging techniques become increasingly used in clinical practice. While normal values for T1, T2 and T2* times are well established for 1.5 Tesla (T) cardiovascular magnetic resonance (CMR), data for 3T remain scarce. Therefore we sought to determine normal reference values relative to gender and age and day to day reproducibility for native T1, T2, T2* mapp...

BACKGROUND Alveolar type II (T2) cells synthesise matrix proteins such as type IV collagen and fibronectin. In contrast, a fetal rat T2 cell line has been shown to synthesise type I and III collagen as well as type IV collagen. To study regulation of collagen production in T2 cells, neonatal T2 cells immortalised by adenoviral 12SE1A gene transfer were used. It was previously reported that this...

Background Osteoporosis affects 1 in 4 women and 1 in 8 men over 50 years and its burden on healthcare resources is enormous. Despite the risk factors and biological processes leading to bone loss have been well studied, little is known about the mechanisms that initiate bone loss in the first place. Osteocytes, marrow adipocytes and haematopoetic cell lines share a common precursor in the marr...

The effect of ascorbic acid (AA) and butylated hydroxyanisole (BHA) supplementation on aflatoxicosis in broiler chickens (1 to 42 days of age) was investigated (250, 500, 1000 and 2000 ppm for AA and BHA) in diet containing 1 ppm total aflatoxin (AF: 76.45% AFB1, 10.52% AFB2, 9.89% AFG1 and 3.14% AFG2). A total of 300 day-old broiler chicks were divided into ten treatment groups (T1=control; T2...

BACKGROUND Iron overload-related heart failure is the principal cause of death in transfusion dependent patients, including those with Thalassemia Major. Linking cardiac siderosis measured by T2* to therapy improves outcomes. T1 mapping can also measure iron; preliminary data suggests it may have higher sensitivity for iron, particularly for early overload (the conventional cut-point for no iro...

In multivariate clinical trials, a key research endpoint is ascertaining whether a candidate treatment is more efficacious than an established alternative. This global endpoint is clearly of high practical value for studies, such as those arising from neuroimaging, where the outcome dimensions are not only numerous but they are also highly correlated and the available sample sizes are typically...