PURPOSE To define the relationship between magnetization transfer and blood-brain-barrier breakdown in multiple sclerosis lesions using gadolinium enhancement as an index of the latter. METHODS Two hundred twenty lesions (high-signal abnormalities on T2-weighted images) in 35 multiple sclerosis patients were studied with gadolinium-enhanced spin-echo imaging and magnetization transfer. Lesion...

We are developing a three-dimensional (3D) model of the rat spinal cord to act as a reliable tool for investigating mechanisms of spinal injury. Segmentation and meshing, by which the spinal geometry is extracted into a model, requires both considerably clear boundaries and high-contrast representation of the cord components: white matter, grey matter, meninges, CSF and IVD. Unfortunately, desp...

We propose the following definition which we call the double truncated (interval) weighted cumulative residual entropy (IWCRE) IEw φ (t1, t2) and the double truncated (interval) weighted cumulative entropy (IWCE) IE w φ(t1, t2) of a RV X|t1 < X < t2: Department of Statistics, Federal University of São Carlos (UFSCar), São Carlos, Brazil. E-mail: sa−[email protected] Department of Statistics, Fer...

Experimental allergic encephalomyelitis (EAE) is the primary experimental model of multiple sclerosis (MS), which involves both inflammation and demyelination and is known to be species-dependent. Spinal cord abnormalities were found in more than 80% of postmortem specimens of MS patients. In the present study, T1, T2 and high b-value q-space diffusion-weighted magnetic resonance imaging (MRI) ...

BACKGROUND AND PURPOSE MR diagnostic of postoperative recurrent cholesteatomas is difficult. Our purpose was to compare multishot fast spin-echo periodically rotated overlapping parallel lines with enhanced reconstruction (PROPELLER) diffusion-weighted MR imaging (DWI) with array spatial sensitivity encoding technique (ASSET) single-shot echo-planar DWI and late postgadolinium T1-weighted MR im...

We compared gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA) enhanced T1-weighted images (T1-Gd) with the histopathological findings in 13 patients with bone or soft tissue sarcomas. Signal intensity of the viable tumor tissue was increased in T1-Gd in 92% of the patients. The necrotic or cystic areas in the tumor were not enhanced, rendering them distinctly. The degree of enhancement of...

To evaluate the magnetic resonance (MR) imaging characteristics of primary malignant melanoma of the sinonasal cavity, T1- and T2-weighted MR images of 12 patients with primary sinonasal melanoma were retrospectively reviewed. Gadolinium-enhanced imaging was performed in seven cases. The MR images were compared with histopathologic results. There were seven melanotic melanomas and five amelanot...