BACKGROUND The effect of peripheral arterial disease (PAD) on outcomes in patients with chronic heart failure (HF) has not been examined in propensity-matched studies. METHODS AND RESULTS Of the 2689 patients with advanced chronic systolic HF in the Beta-Blocker Evaluation of Survival Trial, 441 had a history of PAD. Propensity scores for a history of PAD, calculated for each patient using a ...

Arterial baroreflex control of muscle sympathetic nerve activity (ABRMSNA) is impaired in chronic systolic heart failure (CHF). The purpose of the study was to test the hypothesis that exercise training would improve the gain and reduce the time delay of ABRMSNA in CHF patients. Twenty-six CHF patients, New York Heart Association Functional Class II-III, EF ≤ 40%, peak V̇o2 ≤ 20 ml·kg(-1)·min(-1...

A grade 4/6 systolic murmur, systolic anterior motion of the mitral valve (SAM), and severe mitral regurgitation (MR) documented by two-dimensional Doppler echocardiography developed suddenly on the structurally normal heart of a patient with idiopathic portal hypertension. The patient did not have signs of congestive heart failure and the aforementioned phenomenon disappeared completely when t...

OBJECTIVE The objective of this study was to evaluate whether submicrometer particle is associated with elevated blood pressure (BP) and heart rate (HR). METHODS We measured ambulatory systolic BP (SBP), diastolic BP (DBP), and HR using a portable BP monitoring system and number concentrations of submicrometer particle with a size range of 0.02 to 1 microm (NC0.02-1) by a P-TRAK Ultrafine Par...

1 SIGN Guideline 35: Diagnosis and treatment of heart failure due to left ventricular systolic dysfunction. Available on: http://www.sign.ac.uk/guidelines/fulltext/35/index.html 2 NICE Guideline. Chronic heart failure: Management of chronic heart failure in adults in primary and secondary care. Available from: http://www.nice.org.uk/ 3 Remme WJ, Swedberg K; Task Force for the Diagnosis and Trea...

The European Society of Cardiology has recently published new guidelines on the diagnosis and management of heart failure [1]. This updates previous guidelines and adds several important new recommendations in the light of signiWcant recent advances in knowledge. A number of the sections in the guidelines are readily extended to the older patient with heart failure, but many of the points highl...

Little is known about collagen metabolism in heart failure, with or without left ventricular systolic dysfunction. We studied serum concentrations of the carboxy-terminal propeptide of procollagen type I (PIP), a marker of collagen type-I synthesis, and of the carboxy-terminal telopeptide of collagen type I (ICTP), a marker of collagen type-I degradation, in 70 patients admitted for heart failu...