Biology will almost certainly be the predominant science of the twenty-first century but, for it to become successfully so, it will need to embrace some of the quantitative, analytic, predictive culture that has made physics so successful. This includes the search for underlying principles, systemic thinking at all scales, the development of coarse-grained models, and closer ongoing collaborati...

Obesity and metabolic syndromes are examples whereby excess energy consumption and energy flux disruptions are causative agents of increased fatness. Because other, as yet elucidated, cellular factors may be involved and because potential treatments of these metabolic problems involve systemic agents that are not adipose depot-specific in their actions, should we be thinking of adipose depot-sp...

The Strategic Systemic Thinking (SST) framework is presented as a stepping stone towards enabling the refocusing of organizational analysis in Information Systems (IS). The paper introduces some of the fundamental assumptions regarding the objectives of the SST framework; such as sense making as learning processes build upon communicative actions. The main concepts of the SST framework are pres...

This paper investigates why and how systems approaches can help in evaluating the design of new Information and Communication Technologies (ICTs) as social learning platforms. It focuses on the prototypes created by the research project Virtualis, whose objective is to promote social learning on environmental concepts and practices amongst a variety of stakeholders. The paper presents the princ...

Oral malodor one of the most common complaints with which patients approaches us thinking it can be detrimental to his self-image and confidence. Even though majority of oral malodor is of oral origin, there are multiple other systemic causes that have to be addressed while we diagnose and treat this condition. Most of these patients look up to oral care physicians for expert advice, it is crit...

This paper investigates the advantages of using Systems Thinking and System Dynamics in the analysis of health care systems. It demonstrates that the disappointing results observed in health care management are due to a lack of adoption of systemic methods to study these systems. The paper portrays the consequences and causes of policy resistance in health care systems and how they can be overc...

Bioinspired design has been applied in sustainable (e.g., lightweight structures) to learn from nature and support material structure functionalities. Natural structures usually require modification practice because they were evolved natural environmental conditions that can be different industrial applications. Topology optimization is a method find the optimal solution by considering external...

Darwin's 19th century evolutionary theory of descent with modification through natural selection opened up a multidimensional and integrative conceptual space for biology. We explore three dimensions of this space: explanatory pattern, levels of selection, and degree of difference among units of the same type. Each dimension is defined by a respective pair of poles: law and narrative explanatio...