Abstract This research constructs an esterase-responsive hyperbranched polyprodrug nano pharmaceutical and investigates their antitumor activity. Polyprodrug micelle was prepared by one-pot method based on glutathione (GSH), doxorubicin (DOX), polyethylene glycol (PEG) under the catalyst of N , -dicyclohexylcarbodiimide (DCC), 4-dimethylaminopyridine (DMAP), 1-hydroxybenzotriazole (HOBt). The c...

Chymotrypsin is an important proteolytic enzyme in the human digestive system that cleaves milk proteins through hydrolysis reaction, making it interesting subject to study activity of proteases. In this work, we compared detection chymotrypsin by spectrophotometric dynamic light scattering (DLS) and quartz crystal microbalance (QCM) methods determined limit (LOD), 0.15 ± 0.01 nM for spectropho...

To elucidate important parameters for in vitro toxicity assessment of C(60) and C(70) fullerene colloidal particles, experiments were carried out in culture medium using pulsed field gradient nuclear magnetic resonance (PFG-NMR), asymmetrical flow field-flow fractionation (AFFFF), and dynamic light scattering (DLS) methods. First, the amounts of total and bulk bovine serum albumin (BSA) molecul...

The silver nanoparticle is a good antibacterial material being used as broad-spectrum fungicide, including against some multidrug-resistant strains. Compared with the normal chemical and physical preparation methods, green synthesis has attracted wide attention, because of pharmaceutical activities natural product, mild reaction conditions, environmentally friendly, etc. In this study, nanopart...

본 연구에서는 이산화탄소 지중저장 효율향상을 위한 나노입자(nanoparticle)를 이용하여 나노유체(nanofluid)를 합성하였으며 육안관찰, 동적광산란법(dynamic light scattering, DLS), 유체혼화성시험(fluid miscibility test, FMT), 투과전자현미경(transmission electron microscope, TEM) 측정을 수행하여 유체 안정성을 평가하였다. 나노유체 육안 관찰 결과, 표면을 개질시킨 SiO2는 1 wt% 이상 조건에서 침전되지 않고 안정된 상태를 유지하였다. DLS 및 TEM 측정 상온(25°C)과 고온(100°C)조건에서 평균 입자크기는 나노입자의 정의인 100 nm 이하의 값으로 분산안정성을 확보한 것으로 판단된다. 또한, 유체혼...

The work reports the synthesis and characterization of ternary nanoalloy catalysts silver, bismuth, rhenium from alkaline solutions containing L–cysteine as a complexing agent sodium borohydride reducing agent. UV–Vis spectra dynamic light scattering (DLS) analyses obtained colloids were performed. Additionally, high-resolution transmission electron microscope (HR–TEM) analysis assisted former ...

In the present investigation, an ethanolic fraction (EF) of Lepechinia meyenii (salvia) was prepared and fractionated by gradient column chromatography, main secondary metabolites in EF were identified HPLC-MS. Silver nanoparticles (AgNPs) synthesized conjugated with (salvia). The AgNPs synthesis optimized using Plackett-Burman design response surface methodology (RSM), considering following in...

In the course of the last thirty years, light scattering techniques have been used with increasing effort and attention for the measurement of the thermophysical properties of pure fluids and fluid mixtures. Here, an introduction is given to dynamic light scattering (DLS) as a valuable tool for the measurement of diffusion processes. First, the basic principles of the method and its experimenta...

Abstract This article presents a simple, eco-friendly, and green method for the synthesis of silver nanoparticles (AgNPs) from AgNO 3 solution utilizing an aqueous extract Callisia fragrans leaf. The effects C. leaf extraction conditions were evaluated. Parameters affecting AgNPs, such as volume extract, pH, temperature, reaction time investigated optimized. obtained AgNPs analyzed by UV–Vis sp...