Recent syntheses of azetidines, pyrrolidines, piperidines and azepines through cycloaddition or sigmatropic rearrangements of vinylaziridines are described. Applications to natural product synthesis and mechanistic investigations are also summarized.

Chemoenzymatic syntheses of several NDP-carba-sugars have been successfully carried out, and these essential cofactor analogues are expected to be selective inhibitors of glycosyltransferase enzymes.

Exactly half a century has passed since the launch of the first documented research project (1965 Dendral) on computer-assisted organic synthesis. Many more programs were created in the 1970s and 1980s but the enthusiasm of these pioneering days had largely dissipated by the 2000s, and the challenge of teaching the computer how to plan organic syntheses earned itself the reputation of a "missio...

Dialogical argumentation practice contributes positively to argumentative writing skills. Specifically, deliberative dialogues are effective in promoting argument and counterargument integration students' essays. However, the potential of dialogic activities may be increased if they combined with instructional practices. The primary objective this research is compare impact four intervention pr...

Catalyzed C−H functionalizations have emerged as a transformative platform for molecular syntheses. Despite of indisputable advances, oxidative activations been largely restricted to precious transition metals and stoichiometric amounts chemical oxidants. In contrast, we herein discuss the potential earth-abundant, environmentally-benign 3d activation, which has recently gained major momentum. ...

Tandem and domino reactions constitute economic methodologies to prepare complex molecules starting from simple materials. Especially, combining these powerful procedures asymmetric catalysis allows direct access many elaborated chiral products, including important key intermediates in total syntheses of biologically active compounds. A range various types organocatalysts have already been succ...

This Open Access book includes focused case studies, broad policy syntheses and chapters on knowledge production systems in the field

Guanosine produced by fermentation is one of the nucleosides most readily available on an industrial scale. We have recently developed several processes leading to known antiviral agents starting with guanosine. The processes involve enzymatic transglycosylation for stavudine (d4T), chemical transpurination for acyclovir and ganciclovir, and novel alkylauon for penciclovir and famciclovir. Intr...

From medicines to materials, small organic molecules are indispensable for human well-being. To plan their syntheses, chemists employ a problem solving technique called retrosynthesis. In retrosynthesis, target molecules are recursively transformed into increasingly simpler precursor compounds until a set of readily available starting materials is obtained. Computer-aided retrosynthesis would b...

This Perspective provides a contemporary understanding of the shape evolution of colloidal metal nanocrystals under thermodynamically and kinetically controlled conditions. It has been extremely challenging to investigate this subject in the setting of one-pot synthesis because both the type and number of seeds involved would be changed whenever the experimental conditions are altered, making i...