Bei septischer Arthritis kann die Abgrenzung von anderen Formen der akuten entzündlichen schwierig sein. Bisher dienen zeitaufwendige Synovialflüssigkeitskulturen zur Identifizierung eines Erregers. Der Nachweis einer bakteriellen Infektion könnte jedoch schneller durch Bestimmung des Glukoseverbrauchs bzw. Laktatproduktion erfolgen. Diese Arbeit untersucht, ob Messung dieser Parameter im Synov...

Pigmented villonodular synovitis is a benign proliferative disease involving the synovium. Pigmented villonodular synovitis is rare after replacement arthroplasty and has not been recognised and reported as a cause of failure of unicompartmental knee replacement in the literature.

Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease, primarily characterized by inflamed synovial tissue in multiple joints leading to localized destruction of cartilage and bone. It is a severe disabling disease that affects approximately 1% of the population on a worldwide basis [1]. RA is characterized by hyperplasia of the synovial lining layer and marked infiltration of sy...

The aim of this study was to investigate the efficacy of combined debridement, bone graft and articular cavity sealing using synovium in the treatment of metaphyseal osteomyelitis involving the knee joint. Eleven patients with metaphyseal osteomyelitis, which involved femurs in 4 patients and tibiae in 7, were included. The patients received a novel treatment, which combined debridement, bone g...

OBJECTIVE Synovial inflammation in rheumatoid arthritis (RA) leads to pannus tissue invasion and destruction of cartilage/bone matrix by proteinases. Our intention was to analyze some of the key matrix metalloproteinases (MMPs) in pannus tissue overlying evolving cartilage erosions in RA. METHODS Frozen tissue samples of pannus and synovium from advanced RA and synovium from osteoarthritic pa...

Previous studies have demonstrated that inflammatory cytokines are associated with matrix metalloproteinases (MMPs) and/or lysyl oxidases (LOXs) produced by anterior cruciate ligament (ACL) fibroblasts, which may contribute to the poor healing ability of the ACL. To evaluate whether the synovium also participates in ACL healing, the inflammatory microenvironment of the knee joint cavity was mim...

Synovial injury and healing are complex processes including catabolic effects by proinflammatory cytokines and anabolic processes by anti-inflammatory mediators. Here we examined the expression of pro- versus anti-inflammatory mediators in synovium of patients with diagnostic arthroscopy (control), joint trauma (JT), osteoarthritis (OA), and rheumatoid arthritis (RA). Synovial samples from thes...

OBJECTIVES To assess the effect of an intra-articular presentation of stress (heat shock) proteins (hsp) on joint inflammation. METHODS Wistar rats were sensitised with a suspension of heat killed Mycobacterium tuberculosis in oil in the scruff of the neck and challenged intra-articularly with stress protein or M tuberculosis preparations. Inflammation was assessed by joint swelling and, usin...