Objective In spite of growing evidence of idiopathic normal-pressure hydrocephalus (NPH), a viewpoint about clinical care for idiopathic NPH is still controversial. A continuous divergence of viewpoints might be due to confusing classifications of idiopathic and adult-onset congenital NPH. To elucidate the classification of NPH, we propose that adult-onset congenital NPH should be explicitly di...

ntracranial aneurysms arise in ≈2% of the population, and their rupture causes 3% of all strokes. 1 Their treatment requires safely achieving complete aneurysm occlusion while preserving blood flow in the parent, branching, and perforating vessels. For decades, this task was achieved using classic open approaches, such as the pterional craniotomy (PTC) described by Yasargil and Fox in 1975, whi...

We studied 10 patients who had neurological disorders with a MRI-based diagnosis of perisylvian dysgenesis based on the fact that the parasagittal and centrifugal extremity of the sylvian fissure was abnormally mesial. This abnormality was bilateral in seven cases; in the other three patients, the contralateral sylvian fissure appeared either normal (two cases) or enlarged (open operculum). The...

We mapped the three dimensional (3D) extents and variability of selected sulci in the Alzheimer's brain and explored the relationship between sulcal pattern and patient's cognitive performance. High-resolution MRIs of 10 patients with probable Alzheimer's disease (AD) were linearly transformed into a standard "normalized" 3D atlas (known as the Talairach coordinate system) and, on each relevant...

Advancement in neurovascular imaging has led to detection of abnormalities and normal anatomic variations. Most of anatomical variations in cerebral vasculature are asymptomatic and found incidentally; however, some may increase the risk of aneurysm formation and subsequent subarachnoid or intracranial hemorrhage. Here in, we report fenestration within an azygos A2 segment, as an incidental fin...

BACKGROUND AND PURPOSE Our preliminary report on intrathecal urokinase (UK) infusion into the cisterna magna (CM) with a microcatheter showed good results in terms of vasospasm prevention in humans. In this study, we evaluated the relationship between different urokinase (UK) infusion sites and their effect on vasospasm prevention by using our canine subarachnoid hemorrhage (SAH) model. METHO...