The aim of this study was to develop a multilayer (core/coat) dosage form via co-extrusion, the core providing sustained drug release and the coat immediate drug release. In this study polymers were selected which can be combined in a co-extruded dosage form. Several thermoplastic polymers were hot-melt extruded and evaluated for processability and macroscopic properties (surface smoothness, di...

Objective: The objective of the present study was to formulate a controlled release floating tablet of Olmesartan Medoxomil. Methods: Floating tablets of Olmesartan Medoxomil were prepared by direct compression method using both natural (sodium alginate and carrageenan) and semi synthetic polymers (HPMC K4M, HPMC K100LV and HPMC E50LV).Sodium bicarbonate and calcium carbonate were used as gas g...

previous studies have reported the efficacy of baclofen in the treatment of gastroesophageal reflux diseases (gerd). the objective of present study is to evaluate the effect of co-administration of omeprazole 20 mg/d plus sustained release baclofen (sr baclofen) vs omeprazole 20 mg/d plus placebo on alleviation of symptoms in patients with a diagnosis of gerd. a prospective, double blind, place...

Bi-layer tablet is a new era for the successful development of controlled release formulation along with various features to provide a way of successful drug delivery system. Bi-layer tablet is suitable for sequential release of two drugs in combination, separate two incompatible substances and also for sustained release tablet in which one layer is immediate release as initial dose and second ...

Terapi farmakologi lini pertama pada pasien diabetes melitus terutama tipe II obesitas dan yang memiliki fungsi ginjal normal adalah metformin. Namun, metformin dengan sistem pelepasan segera ditemukan banyak kelemahan seperti menimbulkan efek samping rendahnya kepatuhan pasien. Untuk mengatasi hal tersebut, maka dikembangkan formulasi diperpanjang (extended release). Tujuan penulisan review ar...

The purpose of this study was to investigate the influence of sodium bicarbonate on the physicochemical properties of controlled release hot-melt extruded (HME) tablets containing Eudragit RS PO and/or Eudragit E PO. Acetohydroxamic acid and chlorpheniramine maleate were used as model drugs. Sodium bicarbonate was incorporated into the tablet formulations and the drug release properties and buo...

In the pharmaceutical science, sintering has been described as the mechanism for the strengthening of the mechanical properties of consolidated pharmaceutical powders at elevated temperatures, for solid-bond formation during tablet compression, and for thermal curing of polymer-latex film coatings. The concept of sintering was applied in the investigation of the effect of heating on the mechani...

The aim of the present study was to evaluate seed flour of Vigna mungo (L.) Hepper or Black gram as binding, disintegration nature and sustained release matrix forming material in tablet formulation. The seeds of Vigna mungo swell and form gelatinous mass when it comes in contact with water due to its hydrophilic nature. Indomethacin (NSAIDS) was selected as a model drug because of its poor wat...