People in authority may want to submit some messages anonymously on a famous website, while the maintainers may want to limit the times each person can submit messages on the website so as to save the storage space. More over, when people abuse the system, the maintainers want to find ways to identify their identities. To realize such a system, what we need are some methods that can protect use...

The clinical application of sirolimus (SRL) as an immunosuppressive agent is largely hampered by its narrow therapeutic range. This study focused on developing SRL tablets with a sustained release profile for better safety. SRL was highly water insoluble and its solubility has been efficiently enhanced by preparing self-microemulsifying drug delivery system (SMEDDS). The SRL-SMEDDS was physical...

BACKGROUND Prolonged sitting is linked to various deleterious health outcomes. The alterability of the sitting time (ST)-health relationship is not fully established however and warrants study within populations susceptible to high ST. METHODS We assessed the mortality rates of post-menopausal women from the Women's Health Initiative (WHI) observational study, a 15-year prospective study of p...

Software maintenance is the most time consuming and costly phase of the software development lifecycle. For every dollar spent on creating a new software system, nine dollars is spent on maintaining it throughout its useful life. By the late 1980s maintenance spending accounted for an estimated US$30 billion worldwide. Any activity that even minimally reduces maintenance efforts would yield sig...

Background: Three-dimensional (3D) printing is an innovative technology widely used in dentistry for manufacturing objects of various shapes using different materials. It has gained increasing popularity the field pediatric dentistry, particularly production space maintainers, which serve as a preventive orthodontic treatment following early loss primary molars. Aims: In this systematic review,...

The antennal hearing organs of the fruit fly Drosophila melanogaster boost their sensitivity by an active mechanical process that, analogous to the cochlear amplifier of vertebrates, resides in the motility of mechanosensory cells. This process nonlinearly improves the sensitivity of hearing and occasionally gives rise to self-sustained oscillations in the absence of sound. Time series analysis...

PURPOSE The purpose of this study was to report survival times and problems encountered with bilateral space maintainers placed over a 7 year period. METHODS Charts were reviewed for all patients who had bilateral space maintainers placed between January 1, 1996 and December 31, 2003. Appliance lifetime and problems encountered were recorded and assessed on July 30, 2005, if still in use. Fai...