This paper presents a scatter search (SS) based method for the bi-criteria multi-dimensional knapsack problem. The method is organized according to the usual structure of SS: 1) diversi...cation 2) improvement 3) reference set update 4) subset generation, and 5) solution combination. Surrogate relaxation is used to convert the multi-constraint problem into a single constraint one, which is used...

Multiple Reaction Monitoring (MRM), also known as Selected Reaction Monitoring (SRM), is a powerful targeted proteomics method. The approach is based on the generation of specific quantitative assays for each protein of interest and can be used to accurately quantitate large sets of proteins at high throughput. One challenge in Multiple Reaction Monitoring Proteomics analysis is however to sele...

PURPOSE In computed tomography, metallic objects in the scanning field create the so-called metal artifacts in the reconstructed images. Interpolation-based methods for metal artifact reduction (MAR) replace the metal-corrupted projection data with surrogate data obtained from interpolation using the surrounding uncorrupted sinogram information. Prior-based MAR methods further improve interpola...

Atomic radii and charges are two major parameters used in implicit solvent electrostatics and energy calculations. The optimization problem for charges and radii is underdetermined, leading to uncertainty in the values of these parameters and in the results of solvation energy calculations using these parameters. This paper presents a new method for quantifying this uncertainty in implicit solv...