Respiratory distress syndrome (RDS) is the most common cause of respiratory insufficiency in preterm infants, especially those born at <30 weeks of gestation. Continuous positive airway pressure has been used since the 1970s as a primary mode of treatment for RDS. Surfactant therapy became available in the 1980s and has become the standard care for infants with or at risk for RDS. Surfactant th...

OBJECTIVE To study the effect of a single dose of exogenous bovine surfactant on oxygen and ventilatory requirements of neonates with early chronic lung disease. STUDY DESIGN Prospective pilot study. SETTING Three regional neonatal intensive care units. METHODS Infants 7 to 30 days old with birth weights less than 1500 g were eligible if they required a fraction of inspired oxygen (FIO2) ...

The flow and transport in an alveolus are of fundamental importance to partial liquid ventilation, surfactant transport, pulmonary drug administration, cell-cell signaling pathways, and gene therapy. We model the system in which an alveolus is partially filled with liquid in the presence of surfactants. By assuming a circular interface due to sufficiently strong surface tension and small surfac...

Background Intubation-Surfactant-Extubation (InSurE) and less invasive surfactant administration (LISA) are alternative replacement therapy methods for reducing the complications associated with mechanical ventilation. This study aimed to compare Classic, InSurE, LISA in Very-Low-Birth-Weight infants (VLBWIs) South Korea. Methods The Korean Neonatal Network (KNN) enrolled VLBWIs born between Ja...