Synaptic plasticity in the central nervous system (CNS) of mammals has been discussed for many years. Several forms of synaptic plasticity of mammal’s CNS have been identified, such as those that occur in long-term potentiation (LTP). Different types of LTP have been observed in distinctive areas of the CNS of mammals. The hippocampus is one of the most important areas in the CNS that pla...

This paper presents a numerical study on the vertical (axial) and lateral (flexure) behavior of CFST (Concrete-Filled Steel Tube) columns with active hoop prestress achieved by bolting together two steel half-tubes. Twelve prototype column specimens differing in prestressing force (three levels) gravity loading ratio (four are analyzed; they selected to represent typical ground mid-rise buildin...

The case of a frictionless contact between spherical body and flat metallic glass is studied using mesoscopic description plasticity combined with semi-analytical the elastic deformation in geometry (code ISAAC). Plasticity described by irreversible strain rearrangements maximum deviatoric direction, above some random threshold. In absence adhesion or friction, plastic initiated below surface. ...

1 Despite general agreement on the adaptive importance of plasticity, evidence 2 regarding the role of environmental resource availability is scarce, at least in plants. The 3 main hypothesis was the traditional interspecific trade-off hypothesis applied to dryland 4 species; those most tolerant to drought have lower potential growth, and therefore also 5 have the lowest plasticity -here specif...

foundations behavior is affected by soil behavior which can vary from dilative to contractive depending on the stress level, particularly in dense frictional soils. the zero extension lines (zel) method has been generally developed to predict the foundations behavior. knowledge of soil behavior enables the zel method to predict the general and local shear failure modes. in this paper, a relativ...

In this paper, the bi-directional evolutionary structural optimization (BESO) method is used to find optimal layouts of 3D prestressed concrete beams. Considering the element sensitivity number as the design variable, the mathematical formulation of topology optimization is developed based on the ABAQUS finite element software package. The surface-to-surface contact with a small sliding between...

BACKGROUND The stress hormone corticosterone has the ability both to enhance and suppress synaptic plasticity and learning and memory processes. However, until today there is very little known about the molecular mechanism that underlies the bidirectional effects of stress and corticosteroid hormones on synaptic efficacy and learning and memory processes. In this study we investigate the relati...

Homeostatic processes are believed to contribute to the stability of neuronal networks that are perpetually influenced by Hebbian forms of synaptic plasticity. Whereas the rules governing the targeting and trafficking of AMPA and NMDA subtypes of glutamate receptors during rapid Hebbian LTP have been extensively studied, those that are operant during homeostatic forms of synaptic strengthening ...

The delivery of neurotransmitter receptors into the synaptic membrane is essential for synaptic function and plasticity. However, the molecular mechanisms of these specialized trafficking events and their integration with the intracellular membrane transport machinery are virtually unknown. Here, we have investigated the role of the Rab family of membrane sorting proteins in the late stages of ...

The endochronic theory, developed in the early seventies, allows the plastic behavior of materials to be represented by introducing the notion of intrinsic time. With different viewpoints, several authors discussed the relationship between this theory and the classical theory of plasticity. Two major differences are the presence of plastic strains during unloading phases and the absence of an e...