The islet-specific zinc transporter ZnT8 mediates zinc enrichment in the insulin secretory granules of the pancreatic beta cell. This granular zinc transporter is also a major self-antigen found in type 1 diabetes patients. It is not clear whether ZnT8 can be displayed on the cell surface and how insulin secretion may regulate the level of ZnT8 exposure to extracellular immune surveillance. Her...

Ideally, a tactile stimulator presents information through control of surface normal stress and surface shear stresses. Psy-chophysical experiments measured the eeect of shear stress information on the perception of static stimuli applied normal to the surface. Wax gratings in two diierent orientations and various spatial frequencies were used as stimuli. Elastic layers, representing the anti-a...

Yeast cell-surface display technologies have been widely applied in the fields of food, medicine, and feed enzyme production, including lipase, α-amylase, and endoglucanase. In this study, a treS gene was fused with the yeast cell-surface anchor protein gene Pir1p by overlap PCR, the Pir1p-treS fusion gene was ligated into pPICZαA and pGAPZαA and transformed into P. pastoris GS115 to obtain rec...

In this work, by using density functional theory, the adsorption of Nitramide (NH2NO2) molecule on the surface of pristine, B, As and B&As doped (4,4) armchair aluminum nitride nanotube (AlNNTs) is investigated. From optimized structures the adsorption energy, deformation energy, natural bond orbital (NBO), atom in molecule (AIM), quantum parameters, reduced density gradient (RDG) and molecular...

We have used our ability to control beta-peptide secondary structure in order to explore the effects of conformational stability and geometry of guanidinium display on cell entry. Both of these factors affect the rate and relative amount of beta-peptide accumulation in the cytoplasm and nucleus of live HeLa cells. These beta-peptides do not show significant differences in cell surface binding, ...

A major limitation of existing projection display systems is that they rely on a high quality screen for projecting images. We believe that relaxing this restriction will make projectors more useful and widely applicable. The fundamental problem with using an arbitrary surface for a screen is that the surface is bound to have its own colors and textures (bricks of a wall, painting on a wall, ti...