α-Helix mediated protein-protein interactions are of major therapeutic importance. As such, the design of inhibitors of this class of interaction is of significant interest. We present methodology to modify N-alkylated aromatic oligoamide α-helix mimetics using 'click' chemistry. The effect is shown to modulate the binding properties of a series of selective p53/hDM2 inhibitors.

Electronic supplementary material is available online at https://dx.doi.org/10.6084/m9. figshare.c.3810751. & 2017 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. Flawed analysis and unconvincing interpretation...

Performing more tasks in parallel is a typical feature of complex brains. These are characterized by the coexistence of excitatory and inhibitory synapses, whose percentage in mammals is measured to have a typical value of 20-30%. Here we investigate parallel learning of more Boolean rules in neuronal networks. We find that multi-task learning results from the alternation of learning and forget...

The Karolinska Directed Emotional Faces (KDEF) is one of the most widely used human facial expressions database. Almost a decade after the original validation study (Goeleven et al., 2008), we present subjective rating norms for a sub-set of 210 pictures which depict 70 models (half female) each displaying an angry, happy and neutral facial expressions. Our main goals were to provide an additio...

The corresponding author of this article contacted the journal shortly after the authors’ accepted version of the manuscript was posted online, regarding potential issues with a number of the figures in this paper. Specifically, the first author (M.M.F.) admitted to manipulating some of the data shown in Figs 5, 7, 8 and 9. The existence of potential issues with data in the paper was noted in a...

The shift toward online communication in all realms, from print newspapers to broadcast television, has implications for how the general public consumes information about nanotechnology. The goal of this study is threefold: to investigate who is using online sources for information and news about science and nanotechnology, to examine what the general public is searching for online with regards...

We compare the effectiveness of various tests of three-flavor mixing in future long-baseline neutrino oscillation experiments. We analyze a representative case of mixing in a simplified three-flavor scheme, whose relevant parameters are one neutrino mass-square difference, m, and two mixing angles, ψ and φ. We show that an unambiguous determination of ψ and φ requires flavor-appearance tests in...

In the fall of 2000, a group in the MIT Mathematics Department began work on a suite of computer applets (“MIT Mathlets”) designed to support basic MIT mathematics education. For a report on this work and a review of relevant literature see Miller and Upton [3]. The current state of this collection, along with supplementary material, can be found at http://math.mit.edu/mathlets/. The intent of ...