diabetes mellitus (dm) is a chronic heterogeneous disorder and oxidative stress is a key participant in the development and progression of it and its complications. anti-oxidant status can affect vulnerability to oxidative damage, onset and progression of diabetes and diabetes complications. superoxide dismutase 2 (sod2) is one of the major antioxidant defense systems against free radicals. sod...

We have purified the Cu,Zn superoxide dismutase (CuZnSOD) from the periplasmic space of an Escherichia coli strain unable to synthesize MnSOD and FeSOD. Gel filtration chromatography evidenced that under all the experimental conditions tested the enzyme was monomeric. The catalytic activity of this CuZnSOD was comparable to that of other well characterized dimeric eukaryotic isoenzymes, indicat...

pioglitazone (pg) is one of thiazolidinediones used for the treatment of type ii diabetes mellitus. some reports of its hepatotoxicity exist, but the mechanism of its hepatotoxicity is not well known. in the present study, the protective effect of some atp suppliers are investigated against mitochondrial toxicity of pg in isolated rat mitochondria. mitochondrial viability was investigated by mt...

humic acid as an organic substance can bound heavy metals. it is a best way of decreasing the hazardous effect of heavy metals on plants and thereby on humans. a factorial experiment was conducted in a completely randomized design of seven replications. the treatments consisted of three cadmium levels (0, 2 and 4 mgl-1), and three humic acid levels (0, 100, 1000 mgl-1) added to nutrient solutio...

Background and objective: Diabetes is the most common cause of chronic renal disease globally. Diabetic nephropathy (DN) one serious consequences type 2 diabetes. Melatonin, a powerful antioxidant that has been shown to alleviate DN, deficiency functional relationship between melatonin insulin have linked etiology diabetes mellitus. The purpose this research assess level enzyme activity (catala...

conclusions our findings indicate that fullerenol nanoparticles decrease the brain infarction through enhancement of the sod activity during cerebral ischemia-reperfusion injury. results occlusion of mca induced considerable infarction and lesion in ischemic hemispheres of control ischemic rats (527 ± 59 mm3) in accompany with a decrease in the glutathione content (45%), and sod activity (29%) ...