background and purpose: brain-derived neurotrophic factor (bdnf) is present in the hippocampus and cerebral cortex in high concentrations and has an important role in development, maintenance and regeneration of the nervous system. the aim of this study was to produce active bdnf in e.coli using transforming plasmid. methods: to construct an expression plasmid of bdnf, a gene coding for it was ...

factor v (fv) deficiency is a rare bleeding disorder (rbd) that inherit in autosomal recessive manner. diagnosis of fv deficiency (fvd) is made by routine coagulation tests, fv activity and molecular analysis. in patients with fvd, routine coagulation tests including activated partial thromboplastin time (aptt), prothrombin time (pt) and evenbleeding time (bt) are prolongedwhile thrombin time (...

background: several environmental and psychosocial risk factors are known for adolescent smoking as the single cause of preventable diseases and premature death. this cross-sectional study aimed to determine the prevalence of cigarette smoking, socio-demographic factors associated with cigarette smoking (age, education level, parents’ job, and family’s socioeconomic statues), and the role of fa...

background: single-nucleotide polymorphism (snp) rs2476601 within protein tyrosine phosphatase non-receptor type 22 gene (ptpn22) has been shown to be a risk factor for different autoimmune diseases. this study explored the association of 1858 c/t snp with rheumatoid arthritis (ra) and celiac disease (cd) in a region covering south-west of iran. methods: totally, 52 patients with cd, 120 patien...

background: increasing prevalence of obesity is a major health concern. lifestyle behaviors and diet play an important role in developing childhood obesity. the aim of this study was to determine the association between major dietary patterns and overweight/obesity in a group of iranian school‑aged children. methods: this cross‑sectional study was conducted in isfahan, iran with 637 elementary ...

introduction in this study, we aimed to calculate dose enhancement factor (def) for gold (au) and iron (fe) nanoparticles (nps) in brachytherapy and teletherapy, using monte carlo (mc) method. materials and methods in this study, a new algorithm was introduced to calculate dose enhancement by aunps and fenps for iridium-192 (ir-192) brachytherapy and cobalt-60 (co-60) teletherapy sources, using...

results our results revealed that the serum levels of tgf-β were significantly increased in chb patients in compare to healthy controls. conclusions according to this result, it may be concluded that high serum levels of tgf-β may be a mechanism by which immune response against hbv is suppressed. background the transforming growth factor-β (tgf-β) is an important cytokine with anti-inflammatory...

background the impact factor (if), as the most important criterion for journal’s quality measurement, is affected by the self-citation and number of publications in each journal. objectives to find out the relationship between the number of publications and self-citations in a journal, and their correlations with if. materials and methods self-citations and impact factors of nine top gastroente...

stroke, though rare in children is among the top 10 causes of death in childhood. incidence of ischemic and hemorrhagic stroke is the same in children .we report a case of hemorrhagic stroke in a two year old girl who presented with a limp, inability to stand on the left leg and left hemiparesia. her complaint began 10 days ago after a bout of left clonic seizure. she had been admitted to the h...

background: venous diseases including varicose veins and chronic venous insufficiency are one of the most important pathogenic factors worldwide. high prevalence of varicose veins and its complications is an emerging problem in the twenty-first century. this study aimed to determine the prevalence and associated risk factors of varicose veins in female hairdressers in shahroud, north of iran in...