Catalytic intermolecular hydroamination of vinyl arenes is described. Our initial investigation revealed that a Bi(OTf)3/[Cu(CH3CN)4]PF6 system previously developed for catalytic intermolecular hydroamination of 1,3-dienes was suitable for hydroamination of a styrene with sulfonamides, but the substrate generality of this system was unsatisfactory. Several metals were screened to expand the sub...

We describe a method for the synthesis of sulfonamides through the combination of an organometallic reagent, a sulfur dioxide equivalent, and an aqueous solution of an amine under oxidative conditions (bleach). This simple reaction protocol avoids the need to employ sulfonyl chloride substrates, thus removing the limitation imposed by the commercial availability of these reagents. The resultant...

The diuretic sulfonamides furosemid (FLFur) and hydrochlorothiazid (H2Hyt) were used as ligands in zinc complexes. Spectroscopic data indicate that in [(HFur)Zn(H 2 0 )2 ]C1 0 4 and (HFur)2Zn the furosemid ligand is bound to zinc via its carboxylate and amine functions while (Fur)Zn(NH3)2 is a coordination polymer with Zn-carboxylate and Zn-sulfonimide coordination. A structure determination sh...

The quantification of antibiotics (ABs) in sediments is an analytical challenge, but at the same time, it indispensable to understand fate ABs aquatic systems such as rivers. aim this study was develop a comprehensive method determine 19 classified macrolides, sulfonamides, fluoroquinolones, tetracyclines, clindamycin and trimethoprim river sediments, using combination pressurized liquid extrac...

A general, mild, and convenient method has been developed for the synthesis of various alkyl and aryl sulfinic acid salts and sulfonamides from the corresponding halides. Key to the success of this methodology is the design and facile synthesis of sodium 3-methoxy-3-oxopropane-1-sulfinate (SMOPS), a reagent that serves to introduce the protected sulfinate moiety directly to the substrate, thus ...

Knowledge on interactions among microbial communities colonizing various streambed substrata (e.g. cobbles, sediment, leaf-litter etc.) is essential when investigating the functioning of stream ecosystems. However, these are often forgotten assessing responses aquatic to chemical contamination. Using a microcosm approach, respective impact two sulfonamide antibiotics (sulfamethoxazole and sulfa...

Some novel 3-phenyl-2-[(E)-2-phenylethenyl]-3,4-dihydroquinazolin-4-one derivatives possessing para-sulfonamides groups on the phenyl ring of the 2-phenylethenyl moiety have been synthesized and their COX-2 inhibitory activity evaluated. The stuctures of the synthesized compounds were confirmed  on the basis of  FT-IR, 1H-NMR, 13C-NMR and mass spectral data. The COX-2 inhibition screening assay...

The cyclic trinuclear system, [(en)(3)Pd(3)(4,7-phen)(3)](6+), undergoes a ligand exchange reaction with 5-R-2-hydroxypyrimidine derivatives (HRpymo; R = ethynylferrocene, 5-(dimethylamino)-N-(2-propynyl)-1-naphthalene sulfonamide) to give [(en)(3)Pd(3)(4,7-phen)(2)(Rpymo)](5+), functional supramolecular receptors of mononucleotides.