A dietary combination of sucrose and linoleic acid strongly contributes to the development of metabolic disorders in Zucker fatty rats. However, the underlying mechanisms of the metabolic disorders are poorly understood. We hypothesized that the metabolic disorders were triggered at a stage earlier than the 8 weeks we had previously reported. In this study, we investigated early molecular event...

KIT and / or PDGFRA activation mutation is the initial molecular event of gastrointestinal stromal tumor (GIST), mechanism leading to malignant progression GIST needs be further studied broken through. This study aims understand from perspective metabolic reprogramming provide a new target for treatment GIST. In present study, transcriptome metabolome were used test tissue adjacent normal sampl...

Metabolic syndrome is a multifactorial disorder originating from central obesity through high caloric intake and sedentary lifestyle. increases the risk of type 2 diabetes (T2D) disease, converting it to one costliest chronic diseases, which reduces life quality. A strategy proposed by food industry reduce this problem generation low-caloric products using sweeteners, are compounds that can sub...

As a medicinal and edible plant, basil (Ocimum basilicum Linn. var. pilosum (Willd.) Benth.) has rich nutrition significant economic value. The increase in heat stress caused by global warming adversely affects the growth yield of plants. However, response mechanism to is poorly understood. This work investigated changes phenotype, metabolome, transcriptome under stress. results showed that tri...

The combination of sucrose and starch in the presence of surface-adsorbed salivary α-amylase and bacterial glucosyltransferases increase the formation of a structurally and metabolically distinctive biofilm by Streptococcus mutans. This host-pathogen-diet interaction may modulate the formation of pathogenic biofilms related to dental caries disease. We conducted a comprehensive study to further...

Phosphoenolpyruvate carboxylase (PEPC) is a crucial enzyme that catalyzes an irreversible primary metabolic reaction in plants.Previous studies have used transgenic plants expressing ectopic PEPC forms with diminished feedback inhibition to examine the role of PEPC in carbon and nitrogen metabolism. To date, the in vivo role of PEPC in carbon and nitrogen metabolism has not been analyzed in pla...

Both controversy and confusion exist concerning fructose, sucrose, and high-fructose corn syrup (HFCS) with respect to their metabolism and health effects. These concerns have often been fueled by speculation based on limited data or animal studies. In retrospect, recent controversies arose when a scientific commentary was published suggesting a possible unique link between HFCS consumption and...

Background & aimsHuman milk is the gold standard for infant nutrition. Preterm infants whose mothers are unable to provide sufficient own mother's (OMM), receive pasteurized donor human (DHM). We studied metabolic signatures of OMM and DHM their effect on interplay developing microbiota infant's metabolism.MethodsMetabolic fingerprinting as well urine was performed using liquid chromatography–m...