نتایج جستجو برای: substructure

تعداد نتایج: 4962  

2007
Grzegorz Bancerek Adam Naumowicz

The following propositions are true: (1) Let S, T be non empty relational structures and f be a map from S into T . Suppose f is one-to-one and onto. Then f ·f−1 = idT and f −1 ·f = idS and f−1 is one-to-one and onto. (2) Let X, Y be non empty sets, Z be a non empty relational structure, S be a non empty relational substructure of Z [: X, Y :], T be a non empty relational substructure of (Z ) ,...

2017
Theodore Roman Lu Xie Russell Schwartz

With increasing appreciation for the extent and importance of intratumor heterogeneity, much attention in cancer research has focused on profiling heterogeneity on a single patient level. Although true single-cell genomic technologies are rapidly improving, they remain too noisy and costly at present for population-level studies. Bulk sequencing remains the standard for population-scale tumor g...

2013
Mathew S. Allen Daniel C. Kammer Randy L. Mayes

Recently, a new experimental based substructure formulation was introduced which reduces ill-conditioning due to experimental measurement noise by imposing the connection constraints on substructure modal coordinates instead of the physical interface coordinates. The experimental substructure is tested in a free-free configuration, and the interface is exercised by attaching a flexible transmis...

Journal: :Genetics 2003
Jukka Corander Patrik Waldmann Mikko J Sillanpää

We introduce a Bayesian method for estimating hidden population substructure using multilocus molecular markers and geographical information provided by the sampling design. The joint posterior distribution of the substructure and allele frequencies of the respective populations is available in an analytical form when the number of populations is small, whereas an approximation based on a Marko...

2008
James E. Taylor Arif Babul

In a previous paper, we described a new method for including detailed information about substructure in semi-analytic models of halo formation based on merger trees. In this paper, we compare the predictions of our model with results from self-consistent numerical simulations. We find that in general the two methods agree extremely well, particularly once numerical effects and selection effects...

Journal: :Journal of computational biology : a journal of computational molecular cell biology 2007
Tetsuo Shibuya

Protein structure analysis is a very important research topic in the molecular biology of the post-genomic era. The root mean square deviation (RMSD) is the most frequently used measure for comparing two protein three-dimensional (3-D) structures. In this paper, we deal with two fundamental problems related to the RMSD. We first deal with a problem called the "range RMSD query" problem. Given a...

Journal: :JAMA neurology 2013
Shiv Saidha Elias S Sotirchos Jiwon Oh Stephanie B Syc Michaela A Seigo Navid Shiee Chistopher Eckstein Mary K Durbin Jonathan D Oakley Scott A Meyer Teresa C Frohman Scott Newsome John N Ratchford Laura J Balcer Dzung L Pham Ciprian M Crainiceanu Elliot M Frohman Daniel S Reich Peter A Calabresi

OBJECTIVE To determine the relationships between conventional and segmentation-derived optical coherence tomography (OCT) retinal layer thickness measures with intracranial volume (a surrogate of head size) and brain substructure volumes in multiple sclerosis (MS). DESIGN Cross-sectional study. SETTING Johns Hopkins University, Baltimore, Maryland. PARTICIPANTS A total of 84 patients with...

Journal: :Acta crystallographica. Section D, Biological crystallography 2003
Fabio Dall'Antonia Patrick J Baker Thomas R Schneider

Using the signal of naturally inbuilt or artificially introduced anomalous scatterers to derive initial phases in a macromolecular crystal structure determination has become routine in recent years. In the context of high-throughput crystallography in particular, MAD and SAD (multiple- and single-wavelength anomalous dispersion) methods are central tools. For both techniques, a crucial step is ...

2012
Hans-Christian Ehrlich Matthias Rarey

UNLABELLED BACKGROUND Searching for substructures in molecules belongs to the most elementary tasks in cheminformatics and is nowadays part of virtually every cheminformatics software. The underlying algorithms, used over several decades, are designed for the application to general graphs. Applied on molecular graphs, little effort has been spend on characterizing their performance. Therefor...

Journal: :Genetics and molecular research : GMR 2015
A V C Coelho R R Moura C A J Cavalcanti R L Guimarães P Sandrin-Garcia S Crovella L A C Brandão

Genetic association studies determine how genes influence traits. However, non-detected population substructure may bias the analysis, resulting in spurious results. One method to detect substructure is to genotype ancestry informative markers (AIMs) besides the candidate variants, quantifying how much ancestral populations contribute to the samples' genetic background. The present study aimed ...

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