Downloa nown to early investigators, DNA damage and repair has been a major focus of anticancer therapy he beginning of clinical oncology. From the early days of using x-irradiation, to the development of en mustard analogs, to today's more sophisticated approaches, DNA damage and repair has strongacted our ability to successfully treat human malignancy. This area of basic, translational, and c...

wnloade nown to early investigators, DNA damage and repair has been a major focus of anticancer therapy he beginning of clinical oncology. From the early days of using x-irradiation, to the development of en mustard analogs, to today's more sophisticated approaches, DNA damage and repair has strongacted our ability to successfully treat human malignancy. This area of basic, translational, and c...

Many components of the cell, including lipids, proteins and both nuclear and mitochondrial DNA, are vulnerable to deleterious modifications caused by reactive oxygen species. If not repaired, oxidative DNA damage can lead to disease-causing mutations, such as in cancer. Base excision repair and nucleotide excision repair are the two DNA repair pathways believed to orchestrate the removal of oxi...

wnloade nown to early investigators, DNA damage and repair has been a major focus of anticancer therapy he beginning of clinical oncology. From the early days of using x-irradiation, to the development of en mustard analogs, to today's more sophisticated approaches, DNA damage and repair has strongacted our ability to successfully treat human malignancy. This area of basic, translational, and c...

Downloa nown to early investigators, DNA damage and repair has been a major focus of anticancer therapy he beginning of clinical oncology. From the early days of using x-irradiation, to the development of en mustard analogs, to today's more sophisticated approaches, DNA damage and repair has strongacted our ability to successfully treat human malignancy. This area of basic, translational, and c...

DNA damage, repair and mutations Harry Vrieling Introduction DNA contains the blueprint for the proper development, functioning and reproduction of organisms ranging from bacteria, low eukaryotes to vertebrates like man. It is therefore of extreme importance that both replication, i.e. the duplication of DNA, and the segregation of fully replicated DNA molecules (i.e. the chromosomes) over the ...

DNA is the essential carrier of genetic information in all living cells. How is the huge amount of DNA in organisms from bacteria to humans maintained and protected from the ravages of noxious agents in the environment? The chemical stability of the DNA molecule is not unusually great, DNA undergoes several types of spontaneous modifications, and it can also react with many physical and chemica...

Damage to DNA is a significant issue for all cells, particularly in cancer where DNA repair commonly fails. It is not widely appreciated that many agents that cause damage to DNA, such as radiation and certain cancer chemotherapy drugs, also damage RNA. Given that there is at least as much RNA in a cell as DNA, wherever DNA is damaged by such agents, RNA is surely damaged as well. When the dama...

Nucleotide excision repair, a general repair mechanism for removing DNA damage, is initiated by dual incisions bracketing the lesion. In procaryotes, the dual incisions result in excision of the damage in 12- to 13-nucleotide-long oligomers, and in eucaryotes they result in excision of the damage in the form of 24- to 32-nucleotide-long oligomers. We wished to find out if Archaea perform excisi...

InDrosophila, the Hippo-signaling pathway is awell-known orchestrator of organismal size. Probing whether these mechanisms also mould organogenesis in mammals, James Martin and colleagues disrupted multiple Hippo pathway components in the developing mouse heart. These targets for conditional knockout include the MST kinases (the mammalian Hippo homologues), Salvador (a scaffold protein that bin...