نتایج جستجو برای: subinhibitory concentrations

تعداد نتایج: 306940  

2009
Haihua Feng Hua Xiang Jiyu Zhang Guowen Liu Na Guo Xuelin Wang Xiuping Wu Xuming Deng Lu Yu

Staphylococcus aureus (S. aureus) strains with multiple antibiotic resistances are increasingly widespread, and new agents are required for the treatment of S. aureus. Cryptotanshinone (CT), a major tanshinone of medicinal plant Salvia miltiorrhiza Bunge, demonstrated effective in vitro antibacterial activity against all 21 S. aureus strains tested in this experiment. Affymetrix GeneChips were ...

Journal: :Journal of bacteriology 1977
W F Burke J Spizizen

Two structurally similar compounds were found to inhibit sporulation in Bacillus subtilis 168. A dye, acridine orange, and an antischizophrenic drug, promethazine, blocked spore formation at concentrations subinhibitory to vegetative growth, while allowing synthesis of serine protease, antibiotic, and certain catabolite-repressed enzymes. The sporulation process was sensitive to promethazine th...

Journal: :The Journal of clinical investigation 1985
H F Chambers B J Hartman A Tomasz

In addition to the four typical penicillin-binding proteins (PBPs), a strain of heterogeneously methicillin-resistant Staphylococcus aureus produced an extra 78-kD PBP (PBP 2a) that had a low affinity for nafcillin and penicillin. Addition of nafcillin to cultures of this strain caused a rapid increase in the amount of this PBP in cell membranes. This increase occurred at subinhibitory concentr...

2015
Aleksandra Šmitran Dragana Vuković Ina Gajić Jelena Marinković Lazar Ranin

This study investigated the possible relationship between the invasiveness of group A Streptococcus (GAS) strains and their abilities to adhere to laminin and assessed the effects of subinhibitory concentrations of penicillin and erythromycin on the ability of GAS to adhere to laminin. The adherence of noninvasive and highly invasive isolates of GAS to laminin was significantly higher than the ...

2016
Yuanli Liu Jinan Zhou Yilin Qu Xinguang Yang Guojing Shi Xiuhong Wang Yuzhi Hong Karl Drlica Xilin Zhao

Reactive oxygen species (ROS; superoxide, peroxide, and hydroxyl radical) are thought to contribute to the rapid bactericidal activity of diverse antimicrobial agents. The possibility has been raised that consumption of antioxidants in food may interfere with the lethal action of antimicrobials. Whether nutritional supplements containing antioxidant activity are also likely to interfere with an...

2013
Kannan Balaji Ramalingam Thenmozhi Shunmugiah Karutha Pandian

BACKGROUND & OBJECTIVES Subinhibitory concentrations (sub-MICs) of antibiotics, although not able to kill bacteria, but influence bacterial virulence significantly. Fluoroquinolones (FQs) which are used against other bacterial pathogens creates resistance in non-targeted Streptococcus pyogenes. This study was undertaken to characterize the effect of sub-MICs of FQs on S. pyogenes biofilm format...

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