Background Pharmacovigilance studies are helpful to follow the use of allergen immunotherapy in clinical practice. Industrially manufactured allergen vaccines (VALERGEN) of three mite species (including the tropical species Dermatophagoides siboney and Blomia tropicalis) have been recently introduced country-wide in Cuba for asthma treatment. To assess the safety and efficacy of allergen immuno...

Allergen immunotherapy plays an important role in the treatment of allergic diseases and asthma. This article is a brief review of the current approaches, including patient and allergen selection, routes of administration, and use of standardized allergen vaccines. New approaches offering potentially useful strategies based on recent studies of T-cell epitopes, cytokines, and anti-IgE and DNA v...

Specific immunotherapy (SIT) is an effective treatment modality for allergic diseases when properly implemented. Standard allergen extracts have been shown to be beneficial in the treatment of allergic rhinitis and asthma. It has been shown in many studies that immunotherapy is the only therapeutic approach that may alter the natural course of allergic diseases if administered in appropriate do...

© Copyright The Korean Academy of Asthma, Allergy and Clinical Immunology • The Korean Academy of Pediatric Allergy and Respiratory Disease http://e-aair.org Allergen immunotherapy has been used for more than a century to treat allergic diseases, including allergic rhinitis and asthma, as well as venom-induced anaphylaxis. The efficacy of immunotherapy has been established by many double-blind,...

Allergen specific immunotherapy (ASIT) is the only disease modifying treatment of allergic diseases. A key element in the protective effect is thought to be induction of a specific IgG4 response leading to a decrease in the IgE-mediated allergic symptoms. The effect of ASIT can be ascertained by provocation or skin prick testing. IgE measurement by ImmunoCAP is a sensitive standard procedure fo...

BACKGROUND There is a lack of objective measures of the clinical efficacy of allergen immunotherapy which relies on patients' perception about the effect of this treatment. We studied whether the fraction of exhaled nitric oxide is affected by multiple allergen immunotherapy in polysensitized adult subjects with allergic rhinitis. We also looked for associations between exhaled nitric oxide and...

allergen immunotherapy involves the administration of gradually increasing quantities of specific allergens to patients with ige-mediated conditions until a dose is reached that is effective in reducing disease severity from natural exposure. in the present study we evaluated a period of six years immunotherapy allergic rhinitis and allergic asthma patients with positive skin prick test of comm...

Allergen-specific immunotherapy is the primary pathogenetically substantiated method for treating allergic diseases.
 This treatment decreases severity of clinical symptoms, has disease-modifying effects, and prevents disease progression, asthma development, spread sensitization. A complex interaction between various cells innate adaptive immunity mediates immunological tolerance driven by...

Precision medicine is a medical model aiming to deliver customised healthcare - with medical decisions, practices, and/or products tailored to the individual patient informed but not directed by guidelines. Allergen immunotherapy has unique immunological rationale, since the approach is tailored to the specific IgE spectrum of an individual and modifies the natural course of the disease as it h...

Background Peanut is one of the most common foods responsible for food-induced anaphylaxis in adults. Unfortunately, commonly used allergen-specific immunotherapy has not been successful for the treatment of food allergy because of the high risk of serious side-effects. Therefore, chemically modified allergen extracts with improved safety characteristics are being investigated for its potential...