Aim of this commentary is to report the most recent views about natural history of subclinical hypothyroidism (SH) according to the different etiologies. In children with idiopathic SH the natural evolution is often favourable, with a high percentage of cases reverting to euthyroidism or remaining SH even after a prolonged follow-up. By contrast, the risk of a significant deterioration of thyro...

Introduction Mastitis is the most frequent and costly disease of dairy cattle. Losses due to mastitis can be attributed to both subclinical and clinical disease. Clinical mastitis losses are generally readily apparent and consist of discarded milk, transient reductions in milk yield and premature culling (Fetrow, 2000). Subclinical mastitis is considered the most economically important type of ...

BACKGROUND Recent genome-wide association studies have identified 49 single nucleotide polymorphisms associated with clinical coronary artery disease. The mechanism by which these loci influence risk remains largely unclear. METHODS AND RESULTS We examined the association between a genetic risk score composed of high-risk alleles at the 49 single nucleotide polymorphisms and the degree of sub...

Traditional risk factors are poor screening tests for coronary heart disease, whereas clinical arterial disease represents its strongest predictor. This raises the question whether subclinical arterial disease may also predict coronary disease. Using published data of prospective studies of subclinical arterial disease, we calculated the incidence of coronary event associated with the absence o...

OBJECTIVE To investigate the suitability of power Doppler ultrasonography (PD-US) for the assessment of lymph node (LN) status in RA, evaluating the existence of structural and dynamic modifications in well-characterized stages of the disease. METHODS Ten patients with active disease and five patients in clinical remission underwent complete clinical and PD-US examination of hands, wrists, ax...

AIMS Whereas endogenous carbon monoxide (CO) is cytoprotective at physiologic levels, excess CO concentrations are associated with cardiometabolic risk and may represent an important marker of progression from subclinical to clinical cardiovascular disease (CVD). METHODS AND RESULTS In 1926 participants of the Framingham Offspring Study (aged 57 ± 10 years, 46% women), we investigated the rel...

Accurate diagnosis and treatment of subclinical hypothyroidism (SCH) is challenging in clinical practice because normal limits of TSH differs in various studies [1]. Subclinical Hypothyroidism (SCH) is defined as mild elevation in serum TSH levels with normal fT3 and fT4 concentration. The prevalence of this disease is 4-10% in the general population of United States. Up to 20 % women older tha...

Hyperglycaemia-induced oxidative stress is implicated as a cause of increased whole blood viscosity (WBV), which is a clinically modifiable risk factor for cardiovascular disease (CVD). However, whether or not there is variation in WBV at different stages of diabetes mellitus (DM) has yet to be confirmed. The sensitivity of underlying oxidative stress has also yet to be investigated. A total of...