Human toxicity Digoxin is a very toxic compound, with an estimated lethal dose being only a few milligrams. Nausea and vomiting are early signs of acute digoxin toxicity. Among other symptoms are gastro-intestinal tract (GIT) disorders, abdominal pain, diarrhea, hyperkalemia, and muscle pain and weakness. Since digoxin is a cardiac medicine, its overdoses can have severe and multiple effects on...

Background: With the rapid expansion of insecticide resistance limiting effectiveness insecticide-based vector control interventions, integrated strategies associating larviciding could be appropriate to improve current efforts. The present experimental study assesses laboratory and field efficacy larvicide VectoMax®G on Anopheline Culicine larval stages in Yaoundé. Methods: effect VectoMax®G, ...

The aqueous seed extract of Persea americana Mill (Lauraceae) is used by herbalists in Nigeria for the management of hypertension. As part of our on-going scientific evaluation of the extract, we designed the present study to assess its acute and sub-acute toxicity profiles in rats. Experiments were conducted to determine the oral median lethal dose (LD(50)) and other gross toxicological manife...

The effects of pesticide endosulfan (an organochlorine compound), on the ovaries of bluegill fish (Lepomis macrochirus) were studied. Exposures for 24 hs with histological preparations at 25% (0.25 μg/L), 75 % (0.75 μg/L), and 100 % (1 μg/L) sub lethal concentrations were examined. The control contained an abundance of the different stages of oocytes (Oocytes I, II, III, and IV) and had an inta...

Abstract Antifouling paint particles (APPs) and associated metals have been identified in sediments around boatyards marinas globally, but the effects of APPs on benthic organisms are largely unknown. Sub-lethal endpoints were measured following laboratory exposures harbour ragworm (Hediste diversicolor ) common cockle (Cerastoderma edule) to environmentally relevant concentrations biocidal (‘m...

background: this study aims to investigate the patterns of bioaccumulation and depuration of copper in the selected kidney and liver of capoeta fusca. methods: the fish were collected between september and november 2010 from a qanat in birjand. they were exposed to two types treatments with copper (0.25 and 0.75 mg/l) for a period of 41 days. the fish under study were exposed to the above-menti...

Indiscriminate use of toxic pesticides in agriculture has raised serious concerns worldwide, which led to a steady destruction soil biota as well the overall health ecosystem. The present study was designed evaluate effects selected agrochemicals such cyfluthrin (insecticide), fytran (fungicide) and oxadiargyl (herbicide) on moulting stages springtail Cyphoderus javnaus. Laboratory analysis res...

The study determined the effect of intravenous administration of acutely toxic or sub-lethal doses of Na-oleate-coated Fe3O4 (OC-Fe3O4) nanoparticles (NPs) on liver structure and function in Wistar rats, compared to titanium dioxide (TiO2) NPs and saline-injected controls. The acute study, using a modified OECD 425 progressive dosing procedure, found LD50 values of 59.22 and 36.42 mg/kg for TiO...