The aqueous extract of the pods of Cassia fistula Linn (Leguminosae Caesalpinoideae), cultivated in Ile-Ife, Nigeria were investigated for pharmacological and toxicological properties. The in-vitro effect of Cassia fistula infusion on isolated guinea-pig ileum was examined. The acute and sub-chronic toxicity of the infusion of C. fistula and Cassia acutifolia Del. Pod(Senokot tablet) as the ref...

Endosulfan is an organochlorine insecticide extensively used to control pests of vegetables and fruits and is well absorbed by ingestion, inhalation and skin contact. Its toxicity, depends upon route of administration, vehicle and species and sex of animal. The present study was designed to evaluate the reproductive toxicity of sub chronic dose of endosulfan on male rats. Adult male rats were e...

Objective: The goal of this study was to test the ethanol extract aerial part Blumea mollis (Asteraceae) for acute and sub-chronic toxicity as well anti-inflammatory efficacy.
 Methods: shade dried (0.5 kg) powdered extracted with ethanol. Ethanol extracts used these studies. Acute oral studies were performed per OECD guidelines. effect studied by carrageenan-induced paw edema model in rat...

background: exposure to any xenobiotic can disturb the metabolic activities of particular organs. hence present study is designed to find changes in hepatic biochemistry, histochemistry and histopathology besides serum enzyme levels after acute and sub-acute treatment with mercuric chloride, a heavy metallic compound, in albino rat (rattus norvegicus). materials & methods: thirty albino rats we...

Simple, stable, and low-toxicity chemical solution for deposition of ferroelectric Ca:HfO 2 films.

Introduction: Stress is a main factor influencing brain functions as revealed by the electroencephalogram (EEG) recordings. Moreover, different stress durations seemingly cause perturbations in brain waves and lead to mental disorders. This study investigates the effects of acute, sub-chronic and chronic stress on EEG in rats.  Methods: Twenty-eight Wistar adult male rats were randomly all...

There is the need to integrate existing toxicity data in a coherent framework for extending their domain of applicability as well as their extrapolation potential. This integration would also reduce time and cost-consuming aspects of these tests and reduce animal usage. In this work, based on data extracted from literature, we have assessed the advantages that a dynamic biology-toxicant fate co...