OBJECTIVE Gain-of-function ABCC8/sulfonylurea (SU) receptor 1 mutations cause neonatal diabetes mellitus (NDM) or late-onset diabetes in adult relatives. Given the effectiveness of SU treatment in ABCC8-NDM patients, we further characterized late-onset ABCC8-associated diabetes. RESEARCH DESIGN AND METHODS Seven adult subjects from three NDM families and one family with type 2 diabetes were s...

The activity of ribulose 1,5-diphosphate (RuDP)-carboxylase and RuDP-oxygenase was measured in crude leaf extracts of the tobacco (N . tabacum ) phenotypes which differed with respect to their gene constitution and with respect to their photosynthetic and photorespiratory activity. The green wild type (JWB) which carried the discussed two nuclear factors su and aur in the condition su/su Aur/Au...

We report on time-resolved photometry of the 2005 July superoutburst of the dwarf nova, 2QZ J021927.9-304545. The resultant light curves showed conspicuous superhumps with a period of 0.081113(19) days, confirming the SU UMa nature of the object. Although we missed the maximum phase of the outburst, the amplitude of the superoutburst well exceeded 5 mag. This value is slightly larger than that ...

Abstract In this paper we study fractional initial value problems with Caputo–Fabrizio derivative which involves nonsingular kernel. First apply α - ℓ -contraction and -type F mappings to the existence uniqueness of solutions for such problems. Finally, use some contraction in complete $\mathfrak{F}$ F -metri...

We suggest a model of the large N limit N = 4 D = 4 SU(N) SYM as a gas of 3-branes in a 10 dimensional space. Field theory analysis suggests that this 10 dimensional space does not carry the usual gravity dynamics but rather a contraction of it. Using a non-local transformation some aspects of the dynamics of this system are mapped to the dynamics of standard gravitons on AdS5 × S. In particula...

We discuss the simplest models for the generation of neutrinos masses at tree level and one-loop level. The realization of the different seesaw mechanisms in the context of renormalizable SU(5) and SO(10) theories is reviewed. A new mechanism for the generation of neutrino masses at one-loop level is presented. We discuss the first realization of the Type III seesaw mechanism in the context of ...

Suppressor of Hairless (Su(H)) activity is zygotically required in larval imaginal discs for the singling out of adult sense organ precursor (SOP) cells: loss of Su(H) function results in too many proneural cluster cells adopting the SOP fate, while overexpression of the Su(H) protein prevents SOP specification. Su(H) null mutant alleles are recessive lethal at the late larval and early pupal s...

BACKGROUND Resistive exercise after stroke can improve strength (force-generating capacity) without increasing spasticity (velocity-dependent hypertonicity). However, the effect of resistive load type on muscle activation and co-contraction after stroke is not clear. OBJECTIVE The purpose of this study was to determine the effect of load type (elastic, viscous, or mass) on muscle activation a...

Sulfonylureas (SU), commonly used in the treatment of type 2 diabetes mellitus (T2DM), stimulate insulin secretion by inhibiting adenosine triphosphate (ATP)-sensitive K(+) (KATP) channels in pancreatic β-cells. SU are now known to also activate cyclic adenosine monophosphate (cAMP) sensor Epac2 (cAMP-GEFII) to Rap1 signaling, which promotes insulin secretion. The different effects of various S...