Myocardial ischemia (MI) resulting in infarction is an important cause of mortality and morbidity worldwide. Acute ischaemia rapidly impairs myocardial contractile function. Myocardial dysfunction persisting for several hours after transient non-lethal ischaemia, eventually resulting in full functional recovery is termed as myocardial stunning. Hibernation is now thought to be...

BACKGROUND Despite numerous reports that one or more episodes of brief coronary artery occlusion preconditions the myocardium and dramatically reduces myocardial infarct size produced by a subsequent prolonged ischemia, we recently demonstrated that preconditioning does not attenuate contractile dysfunction in the peri-infarct tissue. However, the specific effects of preconditioning on myocardi...

Recent studies suggest that oxygen-derived free radicals contribute to the pathogenesis of postischemic myocardial dysfunction (myocardial "stunning"). This concept, however, is predicated exclusively on results obtained in open-chest preparations, which are subject to the confounding influence of many unphysiological conditions. The lack of supporting evidence in more physiological animal mode...

In experimental studies in the dog, total proximal coronary artery occlusions of up to 15 minutes result in reversible injury, meaning that the myocytes survive this insult. The 15 minutes of ischemia, however, induce numerous changes in the myocardium, including certain monuments to the brief episode of ischemia that may persist for days. One of these monuments is stunned myocardium, which rep...

OBJECTIVE To amplify the description of myocardial stunning. DESIGN Control versus 30 min after a 20 min no flow ischaemia. EXPERIMENTAL ANIMALS 15 isolated rabbit hearts perfused with erythrocyte suspension. MAIN OUTCOME MEASURES Left ventricular systolic function in terms of aortic flow, peak systolic pressure (LVPmax), dP/dtmax, and the end systolic pressure-volume relation (ESPVR); ea...

results ecls was initiated at a mean of 324.15 ± 197.8 (110 - 950) min from initial trauma. in 4 patients, ecls treatment failed due to an incapability to maintain adequate ecls flow and patient perfusion. in the other 16 patients efficiently supported by ecls, the cardiac index, mean arterial pressure, lactate concentration, pao2, paco2, and ph showed significant improvement with normal values...

the term “stunned myocardium” refers to abnormalities in the myocardial function following reperfusion and is common in on-pump coronary artery bypass grafting (cabg) and is exceedingly rare in off- pump cabg. a 53-year-old man presented with unstable angina due to the severe stenosis of the left anterior descending coronary artery (lad) and the obtuse marginal. laboratory findings and chest x-...

The purpose of this study was to test the hypothesis that abnormal intracellular calcium handling characterizes myocardial stunning. Isolated, isovolumic, buffer-perfused ferret hearts were loaded with the bioluminescent calcium indicator aequorin for simultaneous measurement of individual calcium transients and left ventricular pressure. After 15 minutes of global ischemia and 20 minutes of re...

The customary slaughter method of birds killed for human consumption involves the stunning of several live birds at one time using electrical water baths supplied with constant voltages. The birds are hung upside-down on shackles prior to conveyance through the electrified bath. This system, which is used globally, is increasingly under scrutiny as research suggests that it can be both inhumane...

Over the past 2 to 3 decades, several phenomena have been identified that provide powerful protection against myocardial infarction and other sequelae of ischemia/reperfusion1: myocardial hibernation that is related to stunning,2 ischemic preconditioning,3 delayed or second-window ischemic preconditioning,4 ischemic postconditioning,5 and their pharmacological recruitment. Stunning and hibernat...