In an extensive numerical phenetic survey, a numberof blue, red and gray spored streptomycete strainswere grouped together as Streptomyces cyaneusspecies-group, a taxon which encompasses strainsknown to produce antitumor antibiotics, notably anthracyclines.In the present investigation these and relatedstreptomycetes were the subject of morphological and...

The avermectins (AVM) are macrocyclic lactone derivatives produced by Streptomyces avermitilis, which have potent anthelmintic as well as insecticidal activities (Egerton et al., 1979; Ostlind et aL, 1979; Putter et al., 1981). These compounds consist of four major components (A~a, A:a, Bl~, B2a) and four minor components (A~b, AEb, Bmb, BEb) but it is presumed that all avermectins share a comm...

7-O-Methyl aromadendrin (7-OMA) is an aglycone moiety of one of the important flavonoid-glycosides found in several plants, such as Populus alba and Eucalyptus maculata, with various medicinal applications. To produce such valuable natural flavonoids in large quantity, an Escherichia coli cell factory has been developed to employ various plant biosynthetic pathways. Here, we report the generati...

As a continuation of the first two Thematic Series in the Beilstein Journal of Organic Chemistry on natural products in 2011 and 2013 [1,2], it is my pleasure to present the third issue on this topic. Natural products continue to be an inspiring field of research and an important source of potent biologically active compounds. This was recently highlighted by the fact that last year’s Nobel Pri...

Abamectin (Avermectin B1a), is a natural fermentation product derived from the soil bacterium Streptomyces avermitilis. Abamectin (Avermectin B1a) is widely used as an insecticide, acaricide, and anthelmintic. The present study assessed the effects of repeated subacute and subchronic exposure to the commercial formulation of abamectin (Vertemic, 1.8% EC) in albino male rats. The toxic effects o...

background and purpose: cutaneous infections arise from a homogeneous group of keratinophilic fungi, known as dermatophytes. since these pathogenic dermatophytes are eukaryotes in nature, use of chemical antifungal agents for treatment may affect the host tissue cells. in this study, we aimed to evaluate the antifungal activity of actinomyces species against trichophyton mentagrophytes (abbrevi...