نتایج جستجو برای: stearoyl
تعداد نتایج: 1538 فیلتر نتایج به سال:
The purified multienzyme complex fatty acid synthetase from yeast synthesizes palmitoyland stearoyl-CoA with NADPH, ace@-CoA and malonylCoA as substrates. At least seven different enzymatic steps have been shown to occur in the overall synthesis by the use of appropriate model substrates [l] , .e.g. S-acetoacetyl-N-acetylcysteamine for the @-ketoreductase partial activity. As reported in this c...
We report a 14 ns microcanonical (NVE) molecular dynamics simulation of a fully hydrated bilayer of 1-stearoyl-2-oleoyl-phosphatidyethanolamine. This study describes the structure of the bilayer in terms of NMR order parameters and radial distribution functions, and compares them to experimental results and simulations of other lipids. A focus of this work is the characterization of the lipid-w...
A hallmark of targeted cancer therapies is selective toxicity among cancer cell lines. We evaluated results from a viability screen of over 200,000 small molecules to identify two chemical series, oxalamides and benzothiazoles, that were selectively toxic at low nanomolar concentrations to the same 4 of 12 human lung cancer cell lines. Sensitive cell lines expressed cytochrome P450 (CYP) 4F11, ...
Diacylglycerols composed of one saturated and one unsaturated chain make up the hydrophobic core of many biological membranes. We report here the first crystalline structure of such a mixed chain diacylglycerol. The mixed chain diacylglycerol, 1-stearoyl-3-oleyl-glycerol ( 1,3-SODG) was produced by solution isomerization of 1-stearoyl-2-oleylsn-glycerol. 1.3-SODG was isolated by flash chromatog...
Four novel diterpenoids were isolated from the fruiting bodies of Sarcodon scabrosus (Fr.) Karst. (Boraginaceae) together with neosarcodonin A. One of the novel compounds was elucidated to be a cyathane diterpenoid, namely neosarcodonin O, by its spectral data. The others were characterized as 19-O-linoleoyl, 19-O-oleoyl and 19-O-stearoyl derivatives of sarcodonin A, after comparison with the a...
Cyanide inhibited unesterified fatty acid synthesis but stimulated glyceride synthesis from [1-(14)C]acetate when Spinacia oleracea chloroplasts were incubated in basal media. Both unesterified fatty acid and glyceride accumulation were inhibited when chloroplasts were incubated in a diacylglycerol mode. Stimulation of chloroplast fatty acid synthesis by either exogenous coenzyme A or Triton X-...
Phosphatidylinositol is an important lipid, both as a key membrane constituent and as a participant in essential metabolic processes in all plants and animals, both directly and via a number of metabolites. It is an acidic (anionic) phospholipid that in essence consists of a phosphatidic acid backbone, linked via the phosphate group to inositol (hexahydroxycyclohexane). In most organisms, the s...
An unsaturated fatty acid-requiring mutant derived from Chinese hamster ovary (CHO) cells has been isolated and characterized. This mutant grows normally when oleate or other unsaturated fatty acids are supplemented in the growth medium. Unlike the wild-type CHO cells, growth stops when medium is deprived of unsaturated fatty acid. Whole cell pulse experiments with [14C]acetate or [14C]stearate...
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