Ahs/rcrct: Oneand two sample problems are considered which are divided into subproblems, for each of which a separate rank statistic is obtained. The best combination of these statistics is then compared to the ordinary undivided rank statistic. One easily sees that, under natural conditions, splitting causes no first order efficiency loss. Hence it becomes interestmg to derive second order res...

There is compelling evidence that micronutrient deficiencies can profoundly affect immunity; micronutrient deficiencies are widely seen in HIV, even in asymptomatic patients. Direct relationships have been found between deficiencies of specific nutrients, such as vitamins A and B12, and a decline in CD4 counts. Deficiencies appear to influence vertical transmission (vitamin A) and may affect pr...

the diagnosis of celiac disease (cd) relies on the concordance of pathological, serological, genetic and clinical features. for this reason, the diagnosis of cd is often a challenge. seronegative celiac disease (sncd) is defined by the negativity of anti-tissue transglutaminase antibodies in the presence of a positive histology on duodenal biopsy samples, i. e. inflammatory infiltrate of intra-...

The isolation in recent years of many vitamins in pure form and clinical tests of them have resulted in notable advances in our knowledge of their usefulness in clinical medicine. Dr. Youmans has been one of the pioneers in the study of this particular subject, and therefore is well qualified to write on it. As is evident from the title, as well as the preface, the body of information here gath...

At least 150 different human proteins are anchored to the outer leaflet of the plasma membrane via glycosylphosphatidylinositol (GPI). GPI preassembled in the endoplasmic reticulum is attached to the protein's carboxyl-terminus as a post-translational modification by GPI transamidase. Twenty-two PIG (for Phosphatidyl Inositol Glycan) genes are involved in the biosynthesis and protein-attachment...