نتایج جستجو برای: stat
تعداد نتایج: 11747 فیلتر نتایج به سال:
Both the core JAK-STAT pathway components and their in vivo roles have been widely conserved between vertebrates and invertebrate models such as Drosophila melanogaster. Misregulation of JAK-STAT pathway activity has also been identified as a key factor in the development of multiple human malignancies. Recently, whole genome RNA interference (RNAi) screens in cultured Drosophila cells have ide...
Germ line CQ transcripts can be induced by 1L-4 in the human B cell line, BL-2. Utilizing a IFN-y activation sitelike DNA sequence element located upstream of the L exon, we demonstrated by gel mobility shift assays that IL-4 induced a binding activity in the cytosol and nucleus of BL-2 cells. This factor was designated 1L4 NAF (IL-4-induced nuclear-activating factors) and was identified as a t...
INTRODUCTION Dysregulation of JAK-STAT signaling is a pathogenetic hallmark of myeloproliferative neoplasms (MPNs) arising from several distinct molecular aberrations, including mutations in JAK2, the thrombopoietin receptor (MPL), mutations in negative regulators of JAK-STAT signaling, such as lymphocyte-specific adapter protein (SH2B3), and epigenetic dysregulation as seen with Suppressor of ...
Dd-STAT, the protein that in part controls Dictyostelium stalk cell differentiation, is a structural and functional homolog of metazoan signal transducers and activators of transcription (STATs). Although present during growth and throughout development, Dd-STAT's tyrosine phosphorylation and nuclear localization are developmentally and spatially regulated. Prior to late aggregation, Dd-STAT is...
We present a calculation of the pion quark momentum fraction, $⟨x⟩$, and its third Mellin moment $⟨{x}^{2}⟩$. also obtain directly, for first time, $⟨x⟩$ $⟨{x}^{2}⟩$ kaon using local operators. use an ensemble two degenerate light, strange, charm (${N}_{f}=2+1+1$) maximally twisted mass fermions with clover improvement. The masses are chosen so that they reproduce about 260 MeV 530 MeV. lattice...
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is involved in many cellular processes, including cell growth and differentiation, immune functions and cancer. It is activated by various cytokines, growth factors, and protein tyrosine kinases (PTKs) and regulates the transcription of many genes. Of the four JAK isoforms and seven STAT isoforms known, JAK2 ...
In stat ist ics, a likelihood rat io test is a stat ist ical test used to compare the f it of two models, one of which (the null model) is a special case of the other (the alternative model). The test is based on the likelihood rat io, which expresses how many t imes more likely the data are under one model than the other. This likelihood rat io, or equivalent ly its logarithm, can then be used...
Writer def = new Writer :getid(i):id Writer (i):(ClassDec 0 Writer j run:(LocY j (t stat) :idle:Body 0 Writer;i)) n LY Body 0 Writer;i def = calli;start(j):(LocX jwriteX(j):run:reti;start(true): (t stat) :idle: run:(hcallj;put(^ 1):retj;put(x):reply(x):0 ; abort:0i3 j hreply(y):writeY (y): (t stat) :idle: 1 1 1 1 1 1Body 0 Writer;i ; reply(y):0 + abort:0 j write Y (error): (t stat) :idle: 1 1 1...
Interferons (IFNs) are a family of small regulatory glycoproteins that play a central role in the defense against viral infections. Although IFNs have been initially discovered as antiviral factors, today they are known as an integral part of the cytokine network that affect a wide range of biological processes. IFNs exert their pleiotropic effects through their multisubunit cell surface recept...
Phosphorylation of transcription factor STAT-1 on Y701 regulates subcellular localization whereas phosphorylation of the transactivating domain at S727 enhances transcriptional activity. In this study, we investigate the impact of STAT-1 and the importance of transactivating domain phosphorylation on the induction of peptide-specific CTL in presence of the TLR9-dependent immune adjuvant IC31. S...
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