Intramolecular G-quadruplexes formed by the human telomeric G-rich strand are promising anticancer targets. Here we show that four-repeat human telomeric DNA sequences can adopt two different intramolecular G-quadruplex folds in K+ solution. The two structures contain the (3+1) G-tetrad core, in which three G-tracts are oriented in one direction and the fourth in the opposite direction, with on...

Uprighting springs are typically used with V-slot single brackets or Begg brackets to upright the roots of tipped teeth. In the edgewise technique, these springs provide a reversible and versatile method of controlling anchorage by increasM orthodontists have discovered the utility of a simple, vertically positioned square hole in an orthodontic bracket. The vertical slot, or V-slot, permits th...

Distraction osteogenesis is widely used for the treatment of craniofacial deformities. In patients with cleft lip and palate, distraction osteogenesis can be employed to repair the alveolar cleft. In this report, we describe the management of three cases of unilateral cleft lip and palate by interdental distraction osteogenesis. Interdental distraction osteogenesis of the maxillary bone was per...

We present a new framework based on walks in a graph for analysis and inference in Gaussian graphical models. The key idea is to decompose the correlation between each pair of variables as a sum over all walks between those variables in the graph. The weight of each walk is given by a product of edgewise partial correlation coefficients. This representation holds for a large class of Gaussian g...

This work explores the use of a trailing edge flap for mitigation Vortex Induced Vibrations (VIV) wind turbine blade in standstill. Fluid structure interaction simulations are performed, coupling computational fluid dynamics code with multi-body structural solver. A publicly available 96 m long is selected study, and labeled as IEA 10MW. The effects actuation range [−90°, 90°] analyzed, given s...

This case report highlights the treatment of a skeletal Class II malocclusion with pseudoanodontia that indicated clinical but not radiographic absence of teeth. A 21-year-old female patient presented with a skeletal Class II malocclusion with an orthognathic maxilla and a retrognathic mandible, with Angle’s Class I malocclusion with rotated maxillary and mandibular anteriors with fourteen impa...

In the classical model of tile self-assembly, unit square tiles translate in the plane and attach edgewise to form large crystalline structures. This model of self-assembly has been shown to be capable of asymptotically optimal assembly of arbitrary shapes and, via information-theoretic arguments, increasingly complex shapes necessarily require increasing numbers of distinct types of tiles. We ...

This case report describes the use of an osseointegrated implant to maximize anchorage in a 24-year-old female orthodontic patient with an Angle Class II, Division 1 malocclusion. Preadjusted edgewise appliance therapy was performed by extraction of only the maxillary first premolars. The osseointegrated implant was placed in the median-sagittal region of the hard palate for maximum orthodontic...

The intrusion of an overerupted maxillary molar using traditional orthodontic treatment is a real challenge. The aim of this study was to investigate the envelope of intrusive movements of a maxillary molar in cases using mini-implants as anchorage with partial or full-mouth fixed edgewise appliances. The cusp tips of the pretreatment and postintrusion dental casts were recorded by a three-dime...

Two approaches are currently used to correct overerupted/extruded posterior teeth, the “prosthodontic” and the “orthodontic” one. This report presents a novel orthodontic approach for selective molar intrusion. In two females (26 and 20 years), a modified transpalatal arch (TPA, equivalent to a couple with a 30 g net force) was used to move the tooth bodily. A 50 g force was applied to the over...