Carbon stable isotopes (δ13C) are widely used in ecological studies to understand diet, food web dynamics, and movements of marine fishes. Still, δ13C is influenced by lipid content often requires chemical extraction or mathematical correction. Here, we developed a species-specific correction for white muscle tissue yellowfin tuna (Thunnus albacares), highly migratory finfish considerable econo...

Stable isotope assisted metabolomics techniques have emerged as a valuable tool in systems biology for metabolic flux analysis and pathway discovery (Duckwall et al., 2013; Chokkathukalam et al., 2014; Niedenführ et al., 2015). Traditionally, stable isotope labeling analyses have been highly targeted, meaning that isotopic enrichment of only a small set of metabolites has been analyzed to deduc...

.......................................................................................................................v RÉSUMÉ............................................................................................................................v INTRODUCTION...............................................................................................................1 Stable isotope chem...

Stable isotope labeling (SIL) methods coupled with nanoscale liquid chromatography and high resolution tandem mass spectrometry are increasingly useful for elucidation of the proteome-wide differences between multiple biological samples. Development of more effective programs for the sensitive identification of peptide pairs and accurate measurement of the relative peptide/protein abundance are...