Research has documented the effects of some alternative methods on mood: exercise (Legrand & Heuze, 2007), diet (Appleton et al., 2007) and supplementation with micronutrients such as iron (Beard et al., 2005), fatty acids (Nemets et al, 2002) and St. John’s wort (Mulrow, 2005), for example, have all demonstrated an ability to positively affect mood. It is unknown to what extent this research h...

The author has reported to the ACCP that no significant conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article. Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal. org/misc/reprints.shtml). Correspondence to: Nancy A. Collop, MD, FCCP, Johns Hopkin...

An 85-year-old male patient with a history of hypertension, old anterior wall myocardial infarction and atrial fibrillation was placed on warfarin one year previously. However, he did not comply with regular international normalized ratio (INR) measurements, but kept taking warfarin (5 mg) on a daily basis for almost a year without any problems. After watching a television program about herbal ...

St. John’s wort (Hypericum perforatum L.) (SJW) contains numerous compounds with documented biological activity. Constituents that have stimulated the most interest include the naphthodianthrones, hypericin and pseudohypericin; a broad range of fl avonoids, including rutin, quercetin, quercitrin, miquelianin, amentofl avone, and hyperoside; and the phloroglucinols hyperforin and adhyperforin. A...

Commercially available St. John's wort (Hypericum perforatum) extracts, preparations that are used in the treatment of depression, were examined for the potential to inhibit human cytochrome P450 (CYP) enzyme activities, specifically CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4. Crude extracts demonstrated inhibition of each of these five enzymes, with CYP2D6, CYP2C9, and CYP3A4 being more sensi...

Many women with PMS use alternative therapies, although there has been little research to demonstrate their efficacy. This systematic review provides a comprehensive discussion of dietary supplements and herbal remedies commonly used for premenstrual syndrome (PMS), including calcium, magnesium, vitamin B6, evening primrose oil, Vitex agnus castus, ginkgo biloba and St John’s Wort. Randomized c...

Because use of herbal remedies is increasing, a risk-benefit profile of commonly used herbs is needed. This article provides a clinically oriented overview of the efficacy and safety of ginkgo, St. John's wort, ginseng, echinacea, saw palmetto, and kava. Wherever possible, assessments are based on systematic reviews of randomized clinical trials. Encouraging data support the efficacy of some of...

Depression and anxiety are quite common in the general population due to genetic causes and the stresses of modern life. In response, the therapeutic medications produced by the pharmaceutical industry, while powerful, have not proven adequate solutions, since many side effects are known to occur with prescription drugs. In the natural products industry, there have been few new offerings since ...

St. John's Wort herb extracts often contain undesirable or volitional polysaccharides. As polysaccharides exhibit structure-dependent biological functions in the present study water-soluble polysaccharides were extracted from herb material, fractionated by anion exchange chromatography into four main polysaccharide fractions (denominated as Hp1, Hp2, Hp3 and Hp4) and characterized by HPAEC-PAD,...

BACKGROUND St John's wort (Hypericum perforatum) has been known for centuries for its therapeutic properties and its efficacy as an antidepressant has been confirmed by a growing body of evidence. During the last two decades it has also come to prominence with a wider public, due to advertising efforts across Europe and United States of America. However, its availability without prescription, a...