Constipation in children is a common health problem affecting 0.7% to 29.6% children across the world. Exact etiology for developing symptoms is not clear in children and the majority is considered to have functional constipation. Alteration of rectal and pelvic floor function through the brain-gut axis seems to play a crucial role in the etiology. The diagnosis is often a symptom-based clinica...

Embodied intelligence is the computational approach to the design and understanding of intelligent behavior in embodied and situated agents through the consideration of the strict coupling between the agent and its environment (situatedness), mediated by the constraints of the agent’s own body, perceptual and motor system, and brain (embodiment). The emergence of the field of embodied intellige...

OBJECTIVE The plasma level of interleukin-37 is elevated in patients with acute coronary syndrome, however, its function during the onset and progress of the disease remains unclear. This study aimed to investigate the clinical significance of IL-37 in acute coronary syndrome and its underlying mechanism. METHODS 124 patients with acute coronary syndrome and 40 healthy controls were recruited...

Electronic cigarettes (e-cigarettes) have recently been widely used as a method to conventional smoking cessation or an alternative, especially among young population. The newly identified E-cigarette, vaping, product use associated lung injury (EVALI) and the risk of myocardial infarction may lead catastrophic consequences including death. Herein, we present case ST-elevation (STEMI) accompani...

OBJECTIVE Viruses have a role in the pathogenesis of various forms of arthritis. This study aimed at determining whether viral DNA can be detected in joint samples in the early stages of idiopathic arthritides. METHODS Synovial fluid (SF) and synovial tissue (ST) samples were obtained from 73 patients, with undifferentiated arthritis (n=22), rheumatoid arthritis (n=13), spondyloarthropathy (n...

Dehydroepiandrosterone sulphotransferase (DHEA-ST) is an enzyme that converts dehydroepiandrosterone (DHEA), and some other steroids, into their sulphonated forms. The enzyme catalyses the sulphonation of DHEA on the 3alpha-oxygen, with 3'-phosphoadenosine-5'-phosphosulphate contributing the sulphate. The structure of human DHEA-ST in complex with its preferred substrate DHEA has been solved he...

BACKGROUND Lead aVR is a neglected, however, potentially useful tool in electrocardiography. Our aim was to evaluate its value in clinical practice, by reviewing existing literature regarding its utility for identifying the culprit lesion in acute myocardial infarction (AMI). METHODS Based on a systematic search strategy, 16 studies were assessed with the intent to pool data; diagnostic test ...

BACKGROUND ST-segment elevation in lead aVR (STEaVR) anticipates left main and/or three-vessel disease (LM/3VD) in patients with acute coronary syndromes. STEaVR is generally reciprocal to and accompanied by ST-segment depression (STD) in the precordial leads. SYNTAX score (SS) is an angiographic scoring system and is widely used to evaluate the severity and complexity of coronary artery diseas...