A Subset of Nuclear Receptor Coregulators Act as Coupling Proteins during Synthesis and Maturation of RNA Transcripts Didier Auboeuf,* Dennis H. Dowhan, Martin Dutertre, Natalia Martin, Susan M. Berget, and Bert W. O’Malley* INSERM U685/AVENIR, Centre G. Hayem, Hôpital Saint Louis, 1 Avenue Claude Vellefaux, 75010 Paris, France, and Department of Molecular and Cellular Biology and Department of...

One-half of the world's population lives in cities and towns; this is expected to increase to 70% by 2050. One in three urban dwellers lives in slums. As the urban population grows, so does the number of urban poor. Out of a billion children living in urban areas, approximately 300 million are suffering from exclusion or are at risk of exclusion. Urban poor children are devoid of basic rights o...

Thirty four healthy young male subjects performed symptom limited exercise on Bruce protocol on treadmill machine. Hyperventilation induced labile repolarisation ST-T abnormalities were observed in 2 whereas exercise induced ST changes (upsloping ST depression in 4 and horizontal ST depression in 1) were observed in 5 additional candidates. Changes were unaccompanied by symptoms or signs and qu...

In this video Q&A, we talk to Paul Wicks about the emergence of participant-led research, and discuss how this field may be expected to develop in the near future, particularly with regard to personalized medicine.

The article deals with a Mediaeval hagiographic text dating from 1309, Joinville's work Histoire de Saint Louis. The text is a hagiography or sacred biography, a legal testimony that served in the canonisation process of Louis IX, but, at the same time, also the chronicle of a crusader expedition, that is, the story of a journey which was both an expedition and a pilgrimage. Finally, the text i...

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ST waveform analysis of fetal electrocardiogram (ECG) for intrapartum surveillance (STAN) is a newly introduced method for fetal surveillance. The purpose of this commentary is to assist in the proper use of fetal ECG in combination with cardiotocography (CTG) during labour. Guidelines and recommendations concerning CTG and ST waveform interpretation and classification are stated that were agre...

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We prove that the homeomorphism problem for 2–manifolds can be decided in logspace. The proof relies on Reingold’s logspace solution to the undirected s, t-connectivity problem in graphs.