BACKGROUND Pharmacovigilance programmes monitor and help ensuring the safe use of medicines which is critical to the success of public health programmes. The commonest method used for discovering previously unknown safety risks is spontaneous notifications. In this study we examine the use of data mining algorithms to identify signals from adverse events reported in a phase IIIb/IV clinical tri...

BACKGROUND Duloxetine hydrochloride is approved for the treatment or management of major depressive disorder, generalized anxiety disorder, diabetic peripheral neuropathic pain, chronic musculoskeletal pain, and fibromyalgia in the United States. These conditions affect millions of women, including those of childbearing potential. In pregnancy, pharmacological treatment is justified only if the...

BACKGROUND Healthcare provider spontaneous reporting of suspected adverse events following immunisation (AEFI) is central to monitoring post-licensure vaccine safety, but little is known about how healthcare professionals recognise and report to surveillance systems. The aim of this study was explore the knowledge, experience and attitudes of medical and nursing professionals towards detecting ...

BACKGROUND Adverse drug reactions, (ADRs), constitute an important cause of morbidity and mortality worldwide. Spontaneous adverse drug reaction (ADR) reporting is the bedrock of post-marketing surveillance but under-reporting remains its major drawback. OBJECTIVES This study aimed at evaluating the attitude and practice of ADR among doctors in a tertiary health facility in Oyo State, Nigeria...

background :hypertension is an important public-health challenge worldwide. the prevalence of hypertension greatly varies across countries. the aim of this study was to estimate the prevalence of self-reported hypertension and to determine related factors in a large random sample of tehran population in 2011.   methods : in this cross sectional study, 69173 individuals aged 25–64 years were sel...

introduction: medication errors are among the most serious health errors threatening patient safety in all countries, with major impacts on public health. midwives as members of healthcare systems are prone to such errors. therefore, in this study, we aimed to determine medication errors and the contributing factors among midwives working in maternity units of mashhad university of medical scie...

conclusions most cases for pneumothorax were consisted of the patients with the primary spontaneous pneumothorax; the patients with recurrent pneumothorax were comprised of secondary spontaneous pneumothorax patients and those of majority secondary spontaneous pneumothorax patients were observed with bullous emphysema profile. by looking at the pertinent literature, there are publications showi...

BACKGROUND Recent data suggest that medical injuries, or adverse events, represent an important international problem, and that many are caused by errors. Spontaneous reporting is the main tool used to detect errors and adverse events in most countries, and reporting systems are believed to be important for improving patient safety. Increasingly, such reporting can be done using information sys...

AIMS Current trends in pharmacovigilance systems are veering towards patient involvement in spontaneous reporting of adverse drug reactions (ADRs). The aim of the current systematic review was to identify what is known and what remains unknown with respect to patient reporting to pharmacovigilance systems. METHODS A systematic literature search was conducted in PubMed, CINAHL, Journals@Ovid a...

Currently, pharmacovigilance relies mainly on disproportionality analysis of spontaneous reports. However, the analysis of spontaneous reports is concerned with several problems, such as reliability, under-reporting and insufficient patient information. Longitudinal healthcare data, such as Electronic Patient Records (EPRs) in which comprehensive information of each patient is covered, is a com...