intervertebral joints, with contusion of the cord by the neural arch at the moment of injury, and that spontaneous reduction accounted for the subsequent normal radiographic appearances. This theory was criticised by Cramer and McGowan (1944), and Barnes (1948) showed that a posterior dislocation in flexion that was capable of spontaneous reduction did not produce sufficient narrowing of the sp...

Abstract Purpose The Sonic Hedgehog (Shh) pathway has been associated with a protective role after injury to the central nervous system (CNS). We, therefore, investigated effects of intrathecal Shh-administration in subacute phase thoracic spinal cord (SCI) on secondary processes rats. Methods Twenty-one Wistar rats were subjected clip-contusion/compression SCI at T9. Animals randomized into th...

OBJECTIVE Several studies have shown that, although transplantation of neural stem cells into the contusion model of spinal cord injury (SCI) promotes locomotor function and improves functional recovery, it induces a painful response, Allodynia. Different studies indicate that bone marrow stromal cells (BMSCs) and Schwann cells (SCs) can improve locomotor recovery when transplanted into the inj...

The aim of the present study was to create a feasible specific rat model of isolated bilateral pulmonary contusion (PC) and to evaluate the relationship between severity of hypoxemia and quantity of contusion lesions. Anesthetized rats were placed in a prone position. Injury energy ranging from 2.1 to 3.0 J was produced by a falling weight passed through a specially designed arched shield to th...

Macrophages and microglia are implicated in spinal cord injury, but their precise role is not clear. In the present study, activation of these cells was examined in a spinal cord injury model using 2 different antibodies against ED1 clone and ionized calcium binding adaptor molecule 1 (Iba1). Activation was observed at 1, 4, 8, and 12 weeks after contusion injury and was compared with sham oper...

INTRODUCTION Spinal cord injury without radiological abnormality (SCIWORA) is a rare entity and usually involves the cervical spine. Thoracic spine involvement is very rare due to the stability provided by the rib cage. The mechanisms of injury and pathophysiology are still debatable. CASE PRESENTATION We present a case of an adult male who had road traffic accident and presented with paraple...