This paper studies the impact of the location of a drug substance on the physicochemical and mechanical properties of two types of calcium phosphate granules loaded with seven different contents of ibuprofen, ranging from 1.75% to 46%. These implantable agglomerates were produced by either low or high shear granulation. Unloaded Mi-Pro pellets presented higher sphericity and mechanical properti...

BACKGROUND AND THE PURPOSE OF THE STUDY Extrusion-spheronization is an established technique for the production of pellets for pharmaceutical applications. In this study, the feasibility and influence of the incorporation of acacia, by itself and in combination with tragacanth, on the ability of formulations containing 2 model of drugs (ibuprofen and theophylline) to form spherical pellets by e...

This paper addresses the issue of testing sphericity and identity high-dimensional population covariance matrix when data dimension exceeds sample size. The central limit theorem first four moments eigenvalues is derived using random theory for generally distributed populations. Further, some desirable asymptotic properties proposed test statistics are provided under null hypothesis as size bot...

The behaviour of a non-spherical osmotic motor an axisymmetric catalytic particle self-propelling in a dilute dispersion of reactant particles is considered. In concrast to a conventional osmotic motor that creates differences in concentration, and hence in osmotic pressure, due to asymmetry in reaction rate along its surface (e.g. a Janus particle with reactive and non-reactive patches), a non...

OBJECTIVES We sought to evaluate the geometric changes of the mitral leaflets, local and global LV remodeling in patients with left ventricular dysfunction and varying degrees of Functional mitral regurgitation (FMR). BACKGROUND Functional mitral regurgitation (FMR) occurs as a consequence of systolic left ventricular (LV) dysfunction caused by ischemic or nonischemic cardiomyopathy. Mitral v...

INTRODUCTION Femoral neck axis plotting is of great significance in measuring parameters that define femoral head-neck junction sphericity in the group of patients with the femoroacetabular impingement. Literature methods of femoral neck axis determination have weaknesses associated with the risk of obtaining inaccurate values of certain parameters. OBJECTIVE Method of plotting of the femoral...

We adapt and refine the methods developed in [Abr96] and [DGM] in order to establish the sphericity of the Phan geometries defined in [BGHS07] (type Bn) and [GHS03] (type Cn), and their generalizations. As applications of this sphericity we determine the topological finiteness length of the unitary form of the group Sp 2n (F q2 [t, t]) (Theorem 7.1) and give the first published proof of the Pha...

AIMS Decreased left ventricular (LV) rotation and torsion and even reversed systolic apical rotation have been described in patients with dilated cardiomyopathy (DCM). We sought to test in patients with DCM whether reversed apical rotation with loss of LV torsion is related to the extent of LV remodelling and to the severity of LV dysfunction. METHODS AND RESULTS Fifty consecutive patients wi...