β-lactams are antibiotic molecules able to inhibit cell wall biosynthesis. Among other mechanisms, resistance in Gram-negative bacteria is mostly associated with production of β-lactamase enzymes able to bind and hydrolyze the β-lactam ring. Extended-spectrum β-lactamases extend this ability also to third- and fourth-generation cephalosporins, as well as to carbapenems and monobactams. Vibrio c...

De-escalation of empirical antibiotic therapy is often included in antimicrobial stewardship programs in critically ill patients, but differences in target attainment when antibiotics are switched are rarely considered. The primary objective of this study was to compare the fractional target attainments of contemporary dosing of empirical broad-spectrum β-lactam antibiotics and narrower-spectru...

We continue our previous application of supersymmetric quantum mechanical methods to eigenvalue problems in the context of some deformed canonical commuta-tion relations leading to nonzero minimal uncertainties in position and/or momentum. Here we determine for the first time the spectrum and the eigenvectors of a one-dimensional harmonic oscillator in the presence of a uniform electric field i...

We continue our previous application of supersymmetric quantum mechanical methods to eigenvalue problems in the context of some deformed canonical commuta-tion relations leading to nonzero minimal uncertainties in position and/or momentum. Here we determine for the first time the spectrum and the eigenvectors of a one-dimensional harmonic oscillator in the presence of a uniform electric field i...

The production of β-lactamase is the principal mechanism by which gram-negative bacteria resist the action of β-lactam antibiotics. In recent decades, there has been an alarming explosion in the diversity, global dissemination, host range, and spectrum of activity of β-lactamases. This has been most clearly reflected by the marked increase in infections caused by bacteria that express extended-...

In the context of a two-parameter (α, β) deformation of the canonical commutation relation leading to nonzero minimal uncertainties in both position and momentum, the harmonic oscillator spectrum and eigenvectors are determined by using an extension of the techniques of conventional supersymmetric quantum mechanics combined with shape invariance under parameter scaling. The resulting supersymme...