A turn-on fluorescence sensor, Cu(2+)-c-mpg-C(3)N(4), was developed for detection of CN(-) in aqueous solution by simply mixing cubic mesoporous graphitic carbon nitride (c-mpg-C(3)N(4)) and aqueous solution of Cu(NO(3))(2). The highly sensitive detection of CN(-) with a detection limit of 80 nM is not only possible in aqueous solution but also in human blood serum.

The hybrid semiconducter-macrocycle catalyst TiO2-cobalt phthalocyanine promotes the solar photolysis of aqueous bromoform under anaerobic conditions. The major decomposition products are dibromoethane and HBr. Bromomethane and methane were produced only after prolonged photolysis (30 hr). Acetone, derived from added 2-propanol, was the only observed oxidation product. Preliminary experiments s...

This report shows that glutathione affects ascorbic acid degradation in aqueous solution resulting in a significant stabilization of the vitamin. For the GSH concentrations used in this work the effect was higher on diluted ascorbic acid solutions. It is also shown that for a fixed ascorbic acid concentration, as glutathione concentration increases the degradation reaction shifts from first to ...

Two lamps, including simulated sunlight lamp and UVA-365 nm lamp, were used to study the kinetics and changes of component distribution of NPEOs mixture in solution during photodegradation, as well as the effect of H2O2 on the photodegradation. LC-MS was used to analyze the products of NPEOs photodegradation. It was found that photodegradation of NPEOs occurred under both simulated sunlight and...

In a recent study (1) it was shown that cystine could be decomposed by boiling distilled water with the formation of cysteine, hydrogen sulfide, and elementary sulfur. The decomposition of cysteine under similar conditions should aid in a clearer explanation of the mechanisms involved in the breakdown of these two amino acids. The action of alkaline reagents on cysteine and its derivatives has ...

Colistimethate sodium, increasingly used to treat multidrug-resistant Gram-negative infections, spontaneously hydrolyzes to form colistin A (polymyxin E1) and B (polymyxin E2/B) when mixed with water. High levels of these active breakdown products at the time of administration have been associated with nephrotoxicity and even death. In this study, reconstituted colistimethate sodium was shown t...

The formulation scientist’s key goal is to achieve long-term stability of a drug compound. In the case of protein drugs, stabilization means not only maintaining the native chemical structure, but the native secondary and higher order structures necessary for biological activity (Cleland et al., 1993; Manning et al., 1989). Denaturation, as it is defined in this context, will be any non-native ...