This paper intends to compare the abilities of the two major imaging modalities in nuclear medicine imaging: Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT). The motivations are many-fold: (i) To gain a better understanding of the strengths and limitations of the two imaging modalities in the context of recent and ongoing developments in hardware and so...

In this work, we have developed a new method for SPECT (single photon emission computed tomography) image reconstruction, which has shown the potential to provide higher resolution results than any other conventional methods using the same projection data. Unlike the conventional FBP(filtered backprojection) and EM(expectation maximization) type algorithms, we utilize as much system response in...

The new filtering algorithm EM (expectation maximization) filter is introduced and is validated numerically by applying it to solve the ill-posed inverse problem of reconstructing a time-varying medical image. A linear statespace stochastic approach based on a Markov process is utilized to model the problem, while no precise a-priori information about the underlying dynamics of the physical pro...

| In previous work we developed a list-mode iterative reconstruction algorithm (LMIRA) for SPECT applied to two dimensional image reconstruction. In the 2D case we calculated the emission radiance distribution on the circular enclosure of the object. This part is the forward projection. In the backprojection we sampled the radiance on the intermediate layer using the geometric properties of the...

A method for achieving quantitative single-photon emission computed tomography (SPECT) based upon corrections derived from x-ray computed tomography (CT) data is presented. A CT-derived attenuation map is used to perform transmission-dependent scatter correction (TDSC) in conjunction with non-uniform attenuation correction. The original CT data are also utilized to correct for partial volume ef...

The purpose of this study was to compare the clinical utility of two image reconstruction algorithms in myocardial perfusion SPECT (single-photon emission computed tomography): filtered back-projection (FBP) and ordered subset expectation maximization (OSEM). A rest/stress one-day protocol with 99mTc-MIBI or tetrofosmin was performed on 102 consecutive patients who underwent coronary angiograph...

We implemented a fully-3D ordered subsets expectation maximization (OSEM) algorithm with compensation of attenuation, distance-dependent blurring (DDB) and sensitivity modeling for SPECT performed with cone-beam collimator (CBC). The experimentally obtained detector response to point sources across FOV was fitted to a twodimensional Gauss function with its width (FWHM) varied linearly with the ...