Mutations in a protein designated Parkin were shown to be involved in the pathogenesis of autosomal recessive juvenile parkinsonism. Nothing is known about its regional and subcellular distribution in the mouse. In order to elucidate the Parkin mRNA and protein distribution in the adult mouse, the mouse cDNA was cloned and polyclonal antisera were generated against the N-terminal part of mouse ...

Introduction Splicing is an essential step in the processing of intron-containing pre-mRNAs before their transport out of the nucleus (for a review see [ 13). During the last few years, a significant number of studies have addressed the relationship of pre-mRNA splicing to nuclear structure (for a review see [Z]). Small nuclear ribonucleoprotein particles (snRNPs) as well as several non-snRNP s...

BACKGROUND The epidermal nevus syndromes include different diseases that have the common feature of mosaicism. One of these has been recently identified and named phacomatosis pigmentokeratotica, in analogy to phacomatosis pigmentovascularis. It is characterized by an organoid nevus with sebaceous differentiation, a speckled-lentiginous nevus, and other associated anomalies. It has been hypothe...

The families of 65 patients with systemic sclerosis were examined clinically and serum samples from each subject were tested for antinuclear antibodies (ANA) by immunofluorescence on HEp2 cells and for precipitating antibodies to soluble cellular antigens including Scl-70. Of 217 blood relatives, 58 (27%) had ANA (42 speckled, 13 nucleolar, one centromere, two homogeneous); 22 (10%) had precipi...

The B1C8 monoclonal antibody detects a 180-kDa nuclear matrix-specific protein. The protein is a component of the dense, metabolically active bodies or assemblies revealed by resinless section electron microscopy of the nuclear matrix. These assemblies are scattered through the nuclear interior, enmeshed in a complex network of 11-nm filaments. Resinless section electron microscopy of immunogol...

The (11;19)(q23;p13.1) translocation in acute leukemia leads to the generation of a chimeric protein that fuses MLL to the transcriptional elongation factor ELL. A novel protein was isolated from a yeast 2-hybrid screen with ELL that was named EAF1 for ELL-associated factor 1. Using specific antibodies, the endogenous EAF1 and ELL proteins were coimmunoprecipitated from multiple cell lines. In ...

Recently invented methods of optical tomographic imaging through scattering and absorbing media are presented. In one method, the three-dimensional structure of an object hidden between two biological tissues is recovered from many noisy speckle pictures obtained on the output of a multi-channeled optical imaging system. Objects are recovered from many speckled images observed by a digital came...

The multiplicative model can be used to describe SAR image formation. In this context, the effect and nature of coherent speckling on the spectrum of SAR images is investigated. A method for estimate the spectrum of the backscatter image, based on estimates of the spectra of the speckled image and noise is developed. 1 Introduction Images and signals produced by coherent systems are subject to ...

The Speckled Computing project is a large multisite research project based in Scotland, UK. The aim of the project is to investigate, prototype, and produce tiny (1mm3) computational devices, called Specks, that can be configured into wireless sensor networks, called SpeckNets. Our particular interest is in how people might interact in such environments, what interaction tools they require, and...