The enormous diversity of the naive T cell repertoire is instrumental in generating an immune response to virtually any foreign antigen that can be processed into peptides that bind to MHC molecules. The low frequency of antigen-specific naive T cells, their high activation threshold, and the constrains of antigen-processing and presentation have hampered analysis of naive repertoires to comple...

Abstract T-cells are a critical facet of the adaptive immune system and have been shown in both human animal studies to be essential for control Mycobacterium tuberculosis (Mtb) infection. recognize foreign antigens presented by infected cells via unique T-cell receptor (TCR). Understanding specific TCRs that mediate recognition clearance Mtb-infected is inform vaccine design. We recently descr...

Rat bone marrow (BM) small cells were enriched by velocity sedimentation, further separated by means of free-flow electrophoresis, and characterized using Tand B-cell-specific surface markers. More than 80% of these cells were small lymphocytes by morphological criteria and reacted with lymphocyte-specific antisera. A minority of cells had high electrophoretic mobility (EPM), carried surface an...